The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats.
Atorvastatin
Coproporphyrin
OATP2B1
Journal
Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
25
07
2023
revised:
04
09
2023
accepted:
11
09
2023
medline:
29
9
2023
pubmed:
29
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
Coproporphyrin I (CPI) and III (CPIII) are discussed as biomarkers for organic anion transporting polypeptides (OATPs). We report on CPI and CPIII levels in wildtype, rSlco2b1-knockout, and SLCO2B1-humanized rats at baseline and after administration of atorvastatin, an inhibitor of the CPIII-specific rOATP2B1/hOATP2B1 and the CPI/CPIII-transporting rOATP1B2. OATP-inhibition by atorvastatin leads to significantly increased CPI and CPIII serum levels. However, basal CP serum levels in rSlco2b1-knockout animals were significantly lower (CPI), or unaffected (CPIII). In the presence of atorvastatin, this genotype effect was abolished. In conclusion, our results indicate an unexpected impact of OATP2B1 on CP serum levels in rats.
Identifiants
pubmed: 37770158
pii: S1347-8613(23)00056-7
doi: 10.1016/j.jphs.2023.09.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-174Informations de copyright
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Déclaration de conflit d'intérêts
Declaration of competing interest There are no conflicts of interest to disclose for any of the authors.