Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
25
03
2023
accepted:
21
08
2023
pubmed:
29
9
2023
medline:
29
9
2023
entrez:
28
9
2023
Statut:
ppublish
Résumé
Integrin-mediated focal adhesions are the primary architectures that transmit forces between the extracellular matrix (ECM) and the actin cytoskeleton. Although focal adhesions are abundant on rigid and flat substrates that support high mechanical tensions, they are sparse in soft three-dimensional (3D) environments. Here we report curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation is regulated by the membrane curvatures imposed by the topography of ECM protein fibres. Curved adhesions are mediated by integrin ɑvβ5 and are molecularly distinct from focal adhesions and clathrin lattices. The molecular mechanism involves a previously unknown interaction between integrin β5 and a curvature-sensing protein, FCHo2. We find that curved adhesions are prevalent in physiological conditions, and disruption of curved adhesions inhibits the migration of some cancer cell lines in 3D fibre matrices. These findings provide a mechanism for cell anchorage to natural protein fibres and suggest that curved adhesions may serve as a potential therapeutic target.
Identifiants
pubmed: 37770566
doi: 10.1038/s41556-023-01238-1
pii: 10.1038/s41556-023-01238-1
pmc: PMC10567576
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1453-1464Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL165491
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM141598
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM128142
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS121934
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136568
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. The Author(s).
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