Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial.


Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 10 02 2023
accepted: 25 08 2023
pubmed: 29 9 2023
medline: 29 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

Despite available treatment options, many patients with phenylketonuria (PKU) cannot achieve target plasma phenylalanine (Phe) levels

Identifiants

pubmed: 37770764
doi: 10.1038/s42255-023-00897-6
pii: 10.1038/s42255-023-00897-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1685-1690

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

Références

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Auteurs

Jerry Vockley (J)

Schools of Medicine and Public Health, Departments of Pediatrics and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.

Neal Sondheimer (N)

Synlogic Inc., Cambridge, MA, USA. neal.sondheimer@synlogictx.com.

Marja Puurunen (M)

Synlogic Inc., Cambridge, MA, USA.

George A Diaz (GA)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ilona Ginevic (I)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dorothy K Grange (DK)

Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Cary Harding (C)

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.

Hope Northrup (H)

Department of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth) and Children's Memorial Hermann Hospital, Houston, TX, USA.

John A Phillips (JA)

Vanderbilt University Medical Center, Nashville, TN, USA.

Shawn Searle (S)

Early Clinical & Bioanalytical Research, ICON, Salt Lake City, UT, USA.

Janet A Thomas (JA)

Section of Clinical Genetics and Metabolism, Department of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.

Roberto Zori (R)

Division of Clinical Genetics and Metabolism, University of Florida, Gainesville, FL, USA.

William S Denney (WS)

Synlogic Inc., Cambridge, MA, USA.

Sharon L Ernst (SL)

Synlogic Inc., Cambridge, MA, USA.

Kristina Humphreys (K)

Synlogic Inc., Cambridge, MA, USA.

Nicole McWhorter (N)

Synlogic Inc., Cambridge, MA, USA.

Caroline Kurtz (C)

Synlogic Inc., Cambridge, MA, USA.

Aoife M Brennan (AM)

Synlogic Inc., Cambridge, MA, USA.

Classifications MeSH