Are epigenetic mechanisms and nutrition effective in male and female infertility?
5mc, 5-methylcytosine
AMH, anti-Müllerian hormone
ART, assisted reproductive technique
Aging
CoQ10, coenzyme Q10
CpG dinucleotides, context of guanine
DMR, distinct methylated region
DNMT, DNA methyltransferase
Epigenetic
FSH, follicle stimulating hormone
Female
H2A, H2B, H3 and H4, nucleosomal core histones
HOXA10, HomeoboxA10
HPR, histone-protamine ratio
ICMART, International Committee for Monitoring Assisted Reproductive Technologies
ICR, imprinted control region
ICSI, intracytoplasmic sperm injection
IL-6, interleukin-6
IVF, in vitro fertilisation
Infertility
MAR, matrix attachment region
MTHFR, methylenetetrahydrofolate reductase
Male
NIFT, non-IVF fertility treatment
NTD, neural tube defect
Nutrition
OAT, oligo-astheno-teratozoospermia
P1, P2, potamine 1, potamine 2
PCOS, polycystic ovary syndrome
ROS, reactive oxygen species
SAM, S-adenosylmethionine
SHBG, sex hormone-binding globulin
SNP, single nucleotide polymorphism
SNRPN, small nuclear ribonucleoprotein polypeptide N
TP1, TP2, transition proteins
UMI, unexplained male infertility
VDR, vitamin D receptor
lncRNA, long non-coding RNA
mRNA, coding RNA
miRNA, micro-RNA
ncRNA, non-coding RNA
piRNA, piwi-interacting RNA
siRNA, small interfering RNA
Journal
Journal of nutritional science
ISSN: 2048-6790
Titre abrégé: J Nutr Sci
Pays: England
ID NLM: 101590587
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
04
2023
revised:
15
06
2023
accepted:
16
06
2023
medline:
2
10
2023
pubmed:
29
9
2023
entrez:
29
9
2023
Statut:
epublish
Résumé
This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence of infertility worldwide is 8-12 %, and one out of every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine come into play in the occurrence of infertility. It also interacts with vitamins B12, D and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin and similar factors. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10 % of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Processes that pertain to epigenetics carry alterations which are inherited yet not encoded via the DNA sequence. Nutrition is believed to have an impact over the epigenetic mechanisms which are effective in the pathogenesis of several diseases like infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.
Identifiants
pubmed: 37771507
doi: 10.1017/jns.2023.62
pii: S2048679023000629
pmc: PMC10523291
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e103Informations de copyright
© The Author(s) 2023.
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