A broad inhibitor of acyl-acyl carrier protein synthetases.
Acyl carrier protein
Acyl-acyl carrier protein synthetase
Fatty acid recycling
Fatty acid synthase
Inhibitor
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
27
07
2023
revised:
15
09
2023
accepted:
18
09
2023
medline:
29
9
2023
pubmed:
29
9
2023
entrez:
29
9
2023
Statut:
epublish
Résumé
The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with established antibiotics and those in clinical development. AasS enzymes are surprisingly hard to identify as they show high sequence similarity to other adenylate forming enzymes, and only a handful have been correctly annotated to date. Four recently discovered AasS enzymes from Gram negative bacteria,
Identifiants
pubmed: 37771604
doi: 10.1016/j.bbrep.2023.101549
pii: S2405-5808(23)00130-9
pmc: PMC10522932
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101549Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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