Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.
Radiologically isolated syndrome
functional connectivity
multiple sclerosis
resting-state neural networks
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
3
11
2023
pubmed:
29
9
2023
entrez:
29
9
2023
Statut:
ppublish
Résumé
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS. To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing. RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients' cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus ( RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an "incidental finding" but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
Sections du résumé
BACKGROUND
UNASSIGNED
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.
OBJECTIVE
UNASSIGNED
To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI).
METHODS
UNASSIGNED
Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing.
RESULTS
UNASSIGNED
RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients' cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus (
CONCLUSION
UNASSIGNED
RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an "incidental finding" but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
Identifiants
pubmed: 37772510
doi: 10.1177/13524585231195851
pmc: PMC10619710
mid: NIHMS1935907
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1393-1405Subventions
Organisme : NINDS NIH HHS
ID : R01 NS039422
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Medicine (Baltimore). 2015 Dec;94(49):e1936
pubmed: 26656325
Mult Scler. 2010 Aug;16(8):919-25
pubmed: 20610492
Brain Res Cogn Brain Res. 2001 Jun;11(3):377-85
pubmed: 11339987
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Neuroradiology. 2016 May;58(5):467-74
pubmed: 26847633
Neurobiol Aging. 2012 Oct;33(10):2506-20
pubmed: 22130207
Diabetes. 2012 Jul;61(7):1814-21
pubmed: 22438575
J Psychiatr Res. 2015 Sep;68:309-15
pubmed: 26028549
Appl Neuropsychol Adult. 2023 Jul-Aug;30(4):424-430
pubmed: 34392761
AJNR Am J Neuroradiol. 2013 Dec;34(12):2386-92
pubmed: 23868148
Neuroimage. 2012 Feb 15;59(4):3774-83
pubmed: 22119648
Medicine (Baltimore). 2016 Mar;95(13):e3208
pubmed: 27043685
PLoS One. 2020 Apr 22;15(4):e0231868
pubmed: 32320404
Int J Biomed Imaging. 2010;2010:
pubmed: 20689712
Nat Methods. 2019 Jan;16(1):111-116
pubmed: 30532080
Neurol Neuroimmunol Neuroinflamm. 2015 Apr 09;2(3):e102
pubmed: 25884012
Biomed Res Int. 2015;2015:212693
pubmed: 26413509
J Neurol Sci. 2020 Nov 15;418:117093
pubmed: 32827882
J Pers Assess. 1996 Dec;67(3):588-97
pubmed: 8991972
Eur Radiol. 2017 Apr;27(4):1352-1360
pubmed: 27436017
J Neurosci. 2015 Jan 14;35(2):550-8
pubmed: 25589750
Ann Neurol. 2020 Aug;88(2):407-417
pubmed: 32500558
Mult Scler Relat Disord. 2021 Apr;49:102749
pubmed: 33486398
Neuroimage Clin. 2015 Oct 28;9:640-7
pubmed: 26740917
Insights Imaging. 2022 Mar 28;13(1):63
pubmed: 35347460
Hum Brain Mapp. 2019 Nov 1;40(16):4686-4702
pubmed: 31332912
J Neurol Sci. 2014 Aug 15;343(1-2):91-9
pubmed: 24950898
Neurology. 2009 Mar 3;72(9):800-5
pubmed: 19073949
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
pubmed: 16087444
Medicine (Baltimore). 2016 Jul;95(29):e4310
pubmed: 27442678
Medicine (Baltimore). 2016 Jul;95(27):e4101
pubmed: 27399108
Brain Commun. 2021 Oct 07;3(4):fcab237
pubmed: 34729480
Neurology. 2012 Jan 31;78(5):309-14
pubmed: 22262744
Mult Scler. 2016 Feb;22(2):250-3
pubmed: 26084350
Neuroimage. 2016 Nov 15;142:188-197
pubmed: 27431758
J Neurosci. 2006 Oct 4;26(40):10222-31
pubmed: 17021177
Eur J Neurol. 2017 Jan;24(1):27-36
pubmed: 27633185
Eur J Neurol. 2019 Jul;26(7):1000-1005
pubmed: 30714276
Neuroimage. 2004 Oct;23(2):724-38
pubmed: 15488422
Brain. 2010 Jun;133(Pt 6):1612-21
pubmed: 20356855
Mult Scler. 2016 Oct;22(12):1514-1521
pubmed: 27288053
Front Psychol. 2017 Apr 12;8:557
pubmed: 28446889
Neurology. 2012 Oct 2;79(14):1449-57
pubmed: 22955126