Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
29 09 2023
Historique:
received: 22 03 2023
accepted: 14 09 2023
medline: 5 10 2023
pubmed: 29 9 2023
entrez: 29 9 2023
Statut: epublish

Résumé

Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF

Identifiants

pubmed: 37773239
doi: 10.1038/s41467-023-41687-8
pii: 10.1038/s41467-023-41687-8
pmc: PMC10541875
doi:

Substances chimiques

Tin Fluorides 0
Fluorides Q80VPU408O
ferric oxide 1K09F3G675
Sodium Fluoride 8ZYQ1474W7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6087

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Yue Huang (Y)

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Yuan Liu (Y)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nil Kanatha Pandey (NK)

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Shrey Shah (S)

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.

Aurea Simon-Soro (A)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Stomatology, Dental School, University of Seville, Seville, Spain.

Jessica C Hsu (JC)

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.

Zhi Ren (Z)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Center for Innovation and Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.

Zhenting Xiang (Z)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Dongyeop Kim (D)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Preventive Dentistry, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea.

Tatsuro Ito (T)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Min Jun Oh (MJ)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.

Christine Buckley (C)

Department of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.

Faizan Alawi (F)

Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Yong Li (Y)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Paul J M Smeets (PJM)

Northwestern University Atomic and Nanoscale Characterization Experimental Center, Northwestern University, Evanston, IL, USA.
Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

Sarah Boyer (S)

Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

Xingchen Zhao (X)

Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

Derk Joester (D)

Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

Domenick T Zero (DT)

Department of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.

David P Cormode (DP)

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. david.cormode@pennmedicine.upenn.edu.
Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. david.cormode@pennmedicine.upenn.edu.

Hyun Koo (H)

Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. koohy@upenn.edu.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. koohy@upenn.edu.
Center for Innovation and Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. koohy@upenn.edu.

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