Gender-specific associations between mixture of polycyclic aromatic hydrocarbons and telomere length.
Polycyclic aromatic hydrocarbons
Quantile g-computation
Relative telomere length
Rural population
Journal
Environmental geochemistry and health
ISSN: 1573-2983
Titre abrégé: Environ Geochem Health
Pays: Netherlands
ID NLM: 8903118
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
22
05
2023
accepted:
01
09
2023
medline:
27
11
2023
pubmed:
29
9
2023
entrez:
29
9
2023
Statut:
ppublish
Résumé
Evidence shows the relationships of individual environmental PAHs by their urinary metabolites with relative telomere length (RTL), which may be affected by biological gender differences. Since plasma parent PAHs are not metabolized, it may reflect human exposure to PAHs more realistically in daily life. Thus, exploring joint associations between plasma parent PAHs and RTL is urgent, which may identify the major contributor to its adverse effect. In this study, 2577 participants were obtained from the Henan Rural Cohort. The level of PAHs in blood samples was detected by gas chromatography coupled with tandem mass spectrometry. RTL in blood samples was detected by quantitative polymerase chain reaction. Generalized linear models or quantile g-computation were performed to evaluate the associations between the individual or a mixture of PAHs and RTL. Results from generalized linear models showed that each unit increment in BghiP value corresponded to a 0.098 (95%CI: 0.067, 0.129) increment in RTL for men; each unit increment in BaP, BghiP and Flu value corresponded to a 0.041 (95%CI: 0.014, 0.068), 0.081 (95%CI: 0.055, 0.107) and 0.016 (95%CI: 0.005, 0.027) increment in RTL for women. Results from quantile-g computation revealed that each one-quantile increment in the mixture of 10 PAHs corresponded to a 0.057 (95%CI: 0.021, 0.094) and 0.047 (95%CI: 0.003, 0.091) increment in RTL values of women and men, but these associations were mainly ascribed to three PAHs for women (BaP, Flu and BghiP) and men (BaP, BghiP and Pyr), respectively. Similar results were found in smoking men and cooking women without smoking. Our study found that exposure to 10 PAHs mixture was positively associated with RTL across gender, mainly attributed to Flu, BaP and BghiP, implicating that gender-specific associations may be ascribed to tobacco and cooking smoke pollution. The findings provided clues for effective measures to control PAHs pollutants-related aging disease.Clinical trial registration The Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 06 July 2015. http://www.chictr.org.cn/showproj.aspx?proj=11375 .
Identifiants
pubmed: 37773482
doi: 10.1007/s10653-023-01752-z
pii: 10.1007/s10653-023-01752-z
doi:
Substances chimiques
Polycyclic Aromatic Hydrocarbons
0
Environmental Pollutants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9583-9598Subventions
Organisme : Science and Technology Innovation Team Support Plan of Colleges and Universities in Henan Province
ID : 21IRTSTHN029
Organisme : the Science and Technique Foundation of Henan Province
ID : 222102320029
Organisme : the Foundation of National Key Program of Research and Development of China
ID : 2016YFC0900803
Organisme : China Postdoctoral Science Foundation
ID : 2019M662548, 2021M702934
Organisme : the open project of Key Laboratory of Environment and health, ministry of Education
ID : 2020GWFJJ01
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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