Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors.
Anti-cancer
Apoptosis
Digestive system malignant tumors
Solanum nigrum Linn.
Traditional Chinese Medicine
Journal
Medical oncology (Northwood, London, England)
ISSN: 1559-131X
Titre abrégé: Med Oncol
Pays: United States
ID NLM: 9435512
Informations de publication
Date de publication:
29 Sep 2023
29 Sep 2023
Historique:
received:
18
07
2023
accepted:
18
08
2023
medline:
2
10
2023
pubmed:
30
9
2023
entrez:
29
9
2023
Statut:
epublish
Résumé
Cancer has currently become a serious public health issue in many countries worldwide, and tumors of the digestive system have attracted an increasing number of researchers' due to their numerous types, high proportion and wide area of occurrence. While tumors of the digestive system suffer from high mortality rates, leading to untimely diagnosis and a poor prognosis, making it necessary to update current treatment approaches such as surgery, radiation therapy, and chemotherapy. This highlights the importance of exploring novel therapeutic ideas and targets. Traditional Chinese medicine has a long history of clinical use due to its low toxicity and multi-factor targeting of multiple pathways. As a kind of traditional Chinese herb, S. nigrum Linn. is highly regarded for its proven antitumor activity. The aim of this study was to comprehensively recapitulate and analyze the anti-cancer effects and molecular mechanisms of treatment of gastrointestinal tumors with S. nigrum Linn. extracts and related compounds, including classical signaling pathways mediated by them as well as noncoding RNA pathways associated with tumor suppression. Components that have been found to be responsible for the anti-cancer activity of S. nigrum Linn. include solanine, solasonine, solamargine, a-L-rhhamnopyranose, uttroside B, degalactotigonin, glycoprotein, and other compounds. The underlying mechanisms of anti-cancer activity reflected in this study include apoptosis, cell cycle arrest, autophagy, anti-angiogenesis, suppression of metastasis and invasion, immune escape, and increased sensitivity to radiotherapy. S. nigrum Linn. has great potential in the treatment of tumors of the digestive system, and through further clinical trials and pharmacological mechanisms it has the potential to become a uniform and standardized anti-tumor drug.
Identifiants
pubmed: 37775552
doi: 10.1007/s12032-023-02167-7
pii: 10.1007/s12032-023-02167-7
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Antineoplastic Agents
0
Plant Extracts
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
311Subventions
Organisme : National Natural Science Foundation of China
ID : 82102911
Organisme : China Postdoctoral Science Foundation
ID : 2021M693823
Organisme : Excellent Youth Project of Heilongjiang Natural Science Foundation
ID : YQ2022H011
Organisme : Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University
ID : HYDSYYXQN202102
Organisme : the Fundamental Research Funds for the Provincial Universities
ID : 2021-KYYWF-0259
Organisme : Heilongjiang Provincial Postdoctoral Science Foundation
ID : LBH-Z20180
Organisme : Special Project of the Fourth Affiliated Hospital of Harbin Medical University
ID : HYDSYTB201919
Organisme : Hong Kong Scholars Program, China
ID : XJ2020012
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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