Prostatic proliferative inflammatory atrophy: welcome to the club
cancer
inflammation
prostate
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
21
08
2023
accepted:
04
09
2023
medline:
13
11
2023
pubmed:
30
9
2023
entrez:
30
9
2023
Statut:
ppublish
Résumé
Single-cell RNA sequencing studies in the human prostate have defined a population of epithelial cells with transcriptional similarities to club cells in the lung. However, the localization of club-like cells in the human prostate, and their relationship to prostate cancer, is poorly understood. In a new article in The Journal of Pathology, RNA in situ hybridization was used to demonstrate that club cell markers are expressed in luminal cells adjacent to inflammation in the peripheral zone of the human prostate, where prostate cancer tends to arise. These club-like cells are commonly found in proliferative inflammatory atrophy (PIA) lesions and express markers consistent with an intermediate epithelial cell-type. Future studies will be needed to understand the functional role of club-like cells in human prostate inflammation, regeneration, and disease. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
375-377Subventions
Organisme : NIH HHS
ID : TL1 DK132768
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR001881
Pays : United States
Organisme : NIH HHS
ID : U2C DK129496
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR001881
Pays : United States
Informations de copyright
© 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
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