Effects of an app-based sensorimotor training in promoting neuroplasticity and neuropsychological functioning in frailty: A randomized controlled trial.

Humans Aged Frailty Mobile Applications Frail Elderly / psychology Brain Neuronal Plasticity
Aging Frailty Neuroplasticity Sensorimotor functioning Training app

Journal

Archives of gerontology and geriatrics
ISSN: 1872-6976
Titre abrégé: Arch Gerontol Geriatr
Pays: Netherlands
ID NLM: 8214379

Informations de publication

Date de publication:
12 2023
Historique:
received: 25 07 2023
revised: 01 09 2023
accepted: 14 09 2023
medline: 30 10 2023
pubmed: 1 10 2023
entrez: 30 9 2023
Statut: ppublish

Résumé

Loss of sensorimotor stimulation and maladaptive plastic changes of the brain may play a major role in problematic aging phenomena such as frailty. However, it is not clear if interventions specifically targeting neuroplasticity can reverse or slow the development of frailty. We compared the effect of a tablet-based neuroplasticity-oriented sensorimotor training (experimental group, EG) and a tablet-based relaxation training (control group, CG) on frailty and sensorimotor brain function. Interventions consisted of daily 30 min sessions distributed over 90 days. Assessments took place at baseline, after 60 days, and after 90 days. A total of N = 48 frail older adults (EG: n = 24; CG: n = 24) were assigned to the two groups and reassessed after 60 days. Primary outcomes included frailty phenotype (FP) and frailty index (FI). Sensorimotor brain activity was evaluated using functional magnetic resonance imaging and single-pulse transcranial magnetic stimulation. After 60 days of training, both groups showed a reduction in the number of FP criteria (p < 0.001) with a trend towards a significant time-by-group interaction (p = 0.058) indicating a stronger reduction of frailty in the EG (p < 0.001) compared to the CG (p = 0.039). In addition, pain was significantly reduced in the EG but not the CG. No significant effects were found for measures of brain function. We provided initial evidence that a neuroplasticity-oriented sensorimotor training could be beneficial in counteracting frailty as well as chronic pain. Further studies are needed to determine the potentially underlying neuroplastic mechanisms and the influence of plasticity-related biomarkers as well as their clinical significance. ClinicalTrials.gov NCT03666039 (registered 11 September 2018).

Sections du résumé

BACKGROUND
Loss of sensorimotor stimulation and maladaptive plastic changes of the brain may play a major role in problematic aging phenomena such as frailty. However, it is not clear if interventions specifically targeting neuroplasticity can reverse or slow the development of frailty.
OBJECTIVES
We compared the effect of a tablet-based neuroplasticity-oriented sensorimotor training (experimental group, EG) and a tablet-based relaxation training (control group, CG) on frailty and sensorimotor brain function.
METHODS
Interventions consisted of daily 30 min sessions distributed over 90 days. Assessments took place at baseline, after 60 days, and after 90 days. A total of N = 48 frail older adults (EG: n = 24; CG: n = 24) were assigned to the two groups and reassessed after 60 days. Primary outcomes included frailty phenotype (FP) and frailty index (FI). Sensorimotor brain activity was evaluated using functional magnetic resonance imaging and single-pulse transcranial magnetic stimulation.
RESULTS
After 60 days of training, both groups showed a reduction in the number of FP criteria (p < 0.001) with a trend towards a significant time-by-group interaction (p = 0.058) indicating a stronger reduction of frailty in the EG (p < 0.001) compared to the CG (p = 0.039). In addition, pain was significantly reduced in the EG but not the CG. No significant effects were found for measures of brain function.
DISCUSSION
We provided initial evidence that a neuroplasticity-oriented sensorimotor training could be beneficial in counteracting frailty as well as chronic pain. Further studies are needed to determine the potentially underlying neuroplastic mechanisms and the influence of plasticity-related biomarkers as well as their clinical significance.
TRIAL REGISTRATION
ClinicalTrials.gov NCT03666039 (registered 11 September 2018).

Identifiants

DOI: 10.1016/j.archger.2023.105202 PMID: 37776754
pubmed: 37776754
pii: S0167-4943(23)00280-7
doi: 10.1016/j.archger.2023.105202
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT03666039']

Types de publication

Randomized Controlled Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105202

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Florian Beier (F)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany. Electronic address: florian.beier@zi-mannheim.de.

Martin Löffler (M)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Department of Experimental Psychology, Clinical Psychology, Heinrich Heine University Düsseldorf, Germany; Integrative Spinal Research Group, Department of Chiropractic Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Frauke Nees (F)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.

Robin Bekrater-Bodmann (R)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.

Stefano Silvoni (S)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany.

Simon Desch (S)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Department of Experimental Psychology, Clinical Psychology, Heinrich Heine University Düsseldorf, Germany.

Annette Löffler (A)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany.

Lucrezia Hausner (L)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Lutz Frölich (L)

Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Herta Flor (H)

Medical Faculty Mannheim, Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of an app-based sensorimotor training...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effects of an app-based sensorimotor training...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Effects of an app-based sensorimotor training...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Logiciel › Applications mobiles › Effects of an app-based sensorimotor training...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Personne âgée fragile › Effects of an app-based sensorimotor training...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Effects of an app-based sensorimotor training...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Effects of an app-based sensorimotor training...