Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth.

Adult Child Infant Humans Child, Preschool SARS-CoV-2 / metabolism Multiomics COVID-19 Cytokines / metabolism Interferon-alpha Immunity, Mucosal
SARS-CoV-2 durability infants mucosal immunity multi-omics neonates single-cell ATAC-seq single-cell RNA-seq viral infection

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
12 10 2023
Historique:
received: 27 01 2023
revised: 18 06 2023
accepted: 31 08 2023
medline: 15 11 2023
pubmed: 1 10 2023
entrez: 30 9 2023
Statut: ppublish

Résumé

The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants and young children by analyzing blood samples and weekly nasal swabs collected before, during, and after infection with Omicron and non-Omicron variants. Infection stimulated robust antibody titers that, unlike in adults, showed no sign of decay for up to 300 days. Infants mounted a robust mucosal immune response characterized by inflammatory cytokines, interferon (IFN) α, and T helper (Th) 17 and neutrophil markers (interleukin [IL]-17, IL-8, and CXCL1). The immune response in blood was characterized by upregulation of activation markers on innate cells, no inflammatory cytokines, but several chemokines and IFNα. The latter correlated with viral load and expression of interferon-stimulated genes (ISGs) in myeloid cells measured by single-cell multi-omics. Together, these data provide a snapshot of immunity to infection during the initial weeks and months of life.

Identifiants

DOI: 10.1016/j.cell.2023.08.044 PMID: 37776858
pubmed: 37776858
pii: S0092-8674(23)00978-9
doi: 10.1016/j.cell.2023.08.044
pii:
doi:

Substances chimiques

Cytokines 0
Interferon-alpha 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4632-4651.e23

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI167903
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI144673
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI048638
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NIH HHS
ID : S10 OD025212
Pays : United States
Organisme : NIH HHS
ID : S10 OD021763
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIH HHS
ID : S10 OD026799
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125197
Pays : United States
Organisme : NHLBI NIH HHS
ID : R38 HL143615
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00016
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests B.P. serves on the External Immunology Board of GSK and on the Scientific Advisory Board of Sanofi, Medicago, Boehringer Ingelheim, Icosavax, and EdJen. F.W. is a consultant for Gilead. A.S. is a consultant for Gritstone Bio, Flow Pharma, Moderna, AstraZeneca, Qiagen, Fortress, Gilead, Sanofi, Merck, RiverVest, MedaCorp, Turnstone, NA Vaccine Institute, Emervax, Gerson Lehrman Group and Guggenheim. LJI has filed for patent protection for various aspects of T cell epitope and vaccine design work.

Auteurs

Florian Wimmers (F)

Department of Molecular Medicine, Interfaculty Institute for Biochemistry, University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; DFG Cluster of Excellence 2180 "Image-guided and Functional Instructed Tumor Therapy" (iFIT), University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Baden-Wuerttemberg, Germany.

Allison R Burrell (AR)

Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Environmental and Public Health Sciences, Division of Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Yupeng Feng (Y)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.

Hong Zheng (H)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Prabhu S Arunachalam (PS)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.

Mengyun Hu (M)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.

Sara Spranger (S)

Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Lindsay E Nyhoff (LE)

Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.

Devyani Joshi (D)

Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.

Meera Trisal (M)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.

Mayanka Awasthi (M)

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

Lorenza Bellusci (L)

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

Usama Ashraf (U)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.

Sangeeta Kowli (S)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Katherine C Konvinse (KC)

Department of Pediatrics, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Emily Yang (E)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Michael Blanco (M)

Stanford Genomics Service Center, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Kathryn Pellegrini (K)

Yerkes National Primate Research Center, Atlanta, GA 30024, USA.

Gregory Tharp (G)

Yerkes National Primate Research Center, Atlanta, GA 30024, USA.

Thomas Hagan (T)

Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

R Sharon Chinthrajah (RS)

Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.

Tran T Nguyen (TT)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Alba Grifoni (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

Alessandro Sette (A)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.

Kari C Nadeau (KC)

Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.

David B Haslam (DB)

Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Steven E Bosinger (SE)

Yerkes National Primate Research Center, Atlanta, GA 30024, USA; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Jens Wrammert (J)

Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.

Holden T Maecker (HT)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Paul J Utz (PJ)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Taia T Wang (TT)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Surender Khurana (S)

Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

Purvesh Khatri (P)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Mary A Staat (MA)

Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Bali Pulendran (B)

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: bpulend@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Multi-omique › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Interféron alpha › Multi-omics analysis of mucosal and systemic...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité muqueuse › Multi-omics analysis of mucosal and systemic...