Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 09 2023
Historique:
received: 24 06 2023
accepted: 26 09 2023
medline: 2 10 2023
pubmed: 1 10 2023
entrez: 30 9 2023
Statut: epublish

Résumé

Reduced glutathione (GSH) is a crucial antioxidant with recognized roles in malaria pathogenesis and host response. Despite its importance, reports on the association of GSH with malaria are inconsistent. Therefore, this systematic review and meta-analysis investigated the differences in GSH levels in relation to Plasmodium infection. A comprehensive literature search of six electronic databases (Embase, MEDLINE, Ovid, PubMed, Scopus, and ProQuest) was conducted. Of the 2158 initially identified records, 18 met the eligibility criteria. The majority of studies reported a significant decrease in GSH levels in malaria patients compared with uninfected controls, and this was confirmed by meta-analysis (P < 0.01, Hedges g: - 1.47, 95% confidence interval [CI] - 2.48 to - 0.46, I

Identifiants

pubmed: 37777547
doi: 10.1038/s41598-023-43583-z
pii: 10.1038/s41598-023-43583-z
pmc: PMC10542361
doi:

Substances chimiques

Glutathione GAN16C9B8O

Types de publication

Meta-Analysis Systematic Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16483

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Manas Kotepui (M)

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand. manas.ko@wu.ac.th.

Kwuntida Kotepui (K)

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Aongart Mahittikorn (A)

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. aongart.mah@mahidol.ac.th.

Hideyuki J Majima (HJ)

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Jitbanjong Tangpong (J)

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Hsiu-Chuan Yen (HC)

Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Nephrology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

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