Characterization of Calcium- and Strontium-Polyphosphate Particles Toward Drug Delivery into Articular Cartilage.
articular cartilage
chondrocytes
drug delivery
inorganic polyphosphate
nanoparticles
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
revised:
21
09
2023
received:
27
07
2023
pubmed:
1
10
2023
medline:
1
10
2023
entrez:
1
10
2023
Statut:
aheadofprint
Résumé
Drug delivery into articular cartilage poses many challenges due in part to its lack of vasculature. While intra-articular injections are effective for the local administration of drugs, small molecules are rapidly cleared from the synovial fluid. As such, there is a need to develop effective drug delivery strategies to improve the residence times of bioactive molecules in the joint and elicit a sustained therapeutic effect. In this study, calcium- and strontium-polyphosphate particles are synthesized and characterized as potential drug carriers into articular cartilage. Physicochemical characterization reveals that the particles exhibit a spherical morphology, have a negative zeta potential, and are nanoscale in size. Biological characterization in chondrocytes confirms cellular uptake of the particles and demonstrates both size and concentration-dependent cytotoxicity at high concentrations. Furthermore, treatment of chondrocytes with these particles results in a reduction in cell proliferation and metabolic activity, confirming biological effects. Finally, incubation with cartilage tissue explants suggests successful uptake, despite the particles exhibiting a negative surface charge. Therefore, from the results of this study, these polyphosphate-based particles have potential as a drug carrier into articular cartilage and warrant further development.
Identifiants
pubmed: 37777870
doi: 10.1002/mabi.202300345
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300345Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2017-04593
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 2017-2022
Organisme : Canada Foundation for Innovation
ID : CFI-37732
Organisme : Canada Foundation for Innovation
ID : 2020-2022
Organisme : Stars Career Development Award from the Arthritis Society Canada
ID : STAR-19-0606
Organisme : Stars Career Development Award from the Arthritis Society Canada
ID : 2020-2022
Informations de copyright
© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
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