The creativity of cells: aneural irrational cognition.

aneural cognition associative learning biosemiotics creativity irrationality molecular mimicry

Journal

The Journal of physiology

ISSN: 1469-7793

Titre abrégé: J Physiol

Pays: England

ID NLM: 0266262

Informations de publication

Date de publication:
01 Oct 2023

Historique:

received: 27 06 2023

accepted: 11 09 2023

medline: 1 10 2023

pubmed: 1 10 2023

entrez: 1 10 2023

Statut: aheadofprint

Résumé

Evidence of cognition in aneural cells is well-establish in the literature. This paper extends the exploration of the mechanisms of cognition by considering whether or not aneural cells may be capable of irrational cognition, making associations based on coincidental similarities and circumstantial factors. If aneural cells do harness such semiosic qualities, as with higher-level creativity, this might be how they are able to overcome old algorithms and invent tools for new situations. I will look at three examples of irrational learning in aneural systems in terms of semiotics: (1) generalisation in the immune system, based on viral molecular mimicry, whereby immune cells attack the self, which seems to be an overgeneralisation of an icon sign based on mere similarity, not identity, (2) the classical conditioning of pea plants to trope toward wind as a sign of light, which seems to be an association of an index sign based on mere temporal proximity, and (3) a pharmaceutical intervention to prevent pregnancy, using a conjugate to encrypt self with non-self, which seems to be an example of symbol use. We identify irrational cognition easily when it leads to 'wrong' outcomes, but, if it occurs, it may also lead to favourable outcomes and 'creative' solutions.

Identifiants

DOI: 10.1113/JP284417 PMID: 37777982

pubmed: 37777982

doi: 10.1113/JP284417

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Informations de copyright

Références

Agrawal, B. (2019). Heterologous Immunity: Role in natural and vaccine-induced resistance to infections. Frontiers in Immunology, 10, 2631.

Albert, L. J., & Inman, R. D. (1999). Molecular mimicry and autoimmunity. New England Journal of Medicine, 341(27), 2068-2074.

Alexander, V. N. (2009). The poetics of purpose. Biosemiotics, 2(1), 77-100.

Alexander, V. N. (2011). The biologist's mistress: Rethinking self-organization in art, literature, and nature. Emergent Publications.

Alexander, V. N. (2018). Siri fails the Turing Test: Computation, biosemiosis and Artificial Life. Researches Semiotique/Semiotic Inquiry, 38(3), 231-249.

Alexander, V. N., & Grimes, V. (2017). Fluid biosemiotic mechanisms underlie subconscious habits. Biosemiotics, 10(3), 337-353.

Alexander, V. N., Bacigalupi, J. A., & García, Ó. C. (2021). Living systems are smarter bots: Slime mold semiosis versus AI symbol manipulation. Bio Systems, 206, 104430.

Bacigalupi, J. A. (2013). Refinement: a rigorous description of autonomous adaptive agents. Kybernetes, 42(9/10), 1313-1324.

Bacigalupi, J. A. (2022). Semiogenesis: A dynamic system approach to agency and structure. Biosemiotics, 15(2), 261-284.

Bacigalupi, J. A., & Alexander, V. N. (2021). Creative agency via higher-dimensional constraints. Biosemiotics, 14(1), 87-93.

Baluška, F., Mancuso, S., Volkmann, D., & Barlow, P. W. (2004). Root apices as plant command centres: The unique ‘brain-like’ status of the root apex transition zone. Biologia, 59, 9-17.

Baluška, F., Volkmann, D., & Menzel, D. (2005). Plant synapses: Actin-based adhesion domains for cell-to-cell communication. Trends in Plant Science, 10(3), 106-111.

Baluška, F., & Levin, M. (2016). On having no head: Cognition throughout biological systems. Frontiers in Psychology, 7, 907.

Barbieri, M. (2008). The codes of life: The rules of macroevolution. Springer.

Barbieri, M., & Pinz, R. (2022). Code Biology database: A list of biological codes. Marcello Barbieri Lab. Accessed 13 June 2023. https://www.codebiology.org/database.pdf

Bhattacharjee, S., & Banerjee, M. (2020). Immune thrombocytopenia secondary to COVID-19: A systematic review. SN Comprehensive Clinical Medicine, 2(11), 2048-2058.

Blakemore, R. (1975). Magnetotactic bacteria. Science, 190(4212), 377-379.

Bower, G. (1970). Analysis of a mnemonic device: Modern psychology uncovers the powerful components of an ancient system for improving memory. American Scientist, 58(5), 496-510.

Chen, J., & Yang, Z. (2014). Novel ABP1-TMK auxin sensing system controls ROP GTPase-mediated interdigitated cell expansion in Arabidopsis. Small GTPases, 5, e29711.

Conway, M. (2013). Flashbulb memories. Psychology Press.

Deacon, T. (2011). Incomplete nature: How mind emerged from matter. W. W. Norton & Company.

Denizhan, Y. (2023). Intelligence as a border activity between the modelled and the unmodelled. Angelaki: Journal of the Theoretical Humanities, 28(3), 25-37.

Denizhan, Y., & Karatay, V. (2007). Magnetotactic bacteria as a challenge for semiotic descriptions. 7th Annual Biosemiotics Gathering. 6 June 2007. Groningen, Netherlands.

Dietrich, A., & Kanso, R. (2010). A review of EEG, ERP, and neuroimaging studies of creativity and insight. Psychological bulletin, 136(5), 822.

Doshi, P. (2020). Covid-19: Do many people have pre-existing immunity? British Medical Journal, 370, m3563.

Ermann, J., & Fathman, C. G. (2001). Autoimmune diseases: Genes, bugs and failed regulation. Nature Immunology, 2(9), 759-761.

Etymonline. (2003). Bucket. In Eytmonline.com dictionary. Accessed 7 June 2023. https://www.etymonline.com/search?q=kick+the+bucket

Favareau, D. (2015a). Creation of the relevant next: How living systems capture the power of the adjacent possible through sign use. Progress in Biophysics and Molecular Biology, 119(3), 588.

Favareau, D. (2015b). Symbols are grounded not in things, but in scaffolded relations and their semiotic constraints (or how the referential generality of symbol scaffolding grows minds). Bosemiotics, 8(2), 235-255.

Gagliano, M., Vyazovskiy, V. V., Borbély, A. A., Grimonprez, M., & Depczynski, M. (2016). Learning by association in plants. Scientific Reports, 6(1), 38427.

Halliday, K. J., Martínez-García, J. F., & Josse, E.-M. (2009). Integration of light and auxin signalling. Cold Spring Harbor Perspectives in Biology, 1(6), a001586.

Harvey, J. (2013). Sensory perception: Lessons from synesthesia: Using synesthesia to inform the understanding of sensory perception. Yale Journal of Biology and Medicine, 86(2), 203-216.

Hodcroft, E. B. (2022). CoVariants: SARS-CoV-2 mutations and variants of interest. Accessed on 5 June 2023. https://covariants.org/shared-mutations

Hoffmeyer, J. (2007). Semiotic scaffolding of living systems. In M. Barbieri (Ed.), Introduction to biosemiotics: The new biological synthesis (pp. 149-166). Springer.

Jung-Beeman, M., Bowden, E. M., Haberman, J., Frymiare, J. L., Aradmbel- Liu, S., Greenblatt, R., Reber, P. J., & Kounios, J. (2004). Neural activity when people solve verbal problems with insight. PLoS Biology, 2(4), 500-510.

Kanduc, D. (2020). From anti-SARS-CoV-2 immune responses to COVID-19 via molecular mimicry. Antibodies, 9(3), 33.

Kasama, T., Pósfai, M., Chong, R. K., Finlayson, A. P., Buseck, P. R., Frankel, R. B., & Dunin-Borkowski, R. E. (2006). Magnetic properties, microstructure, composition, and morphology of greigite nanocrystals in magnetotactic bacteria form electron holography and tomography. American Mineralogist, 91(8-9), 1216-1229.

Kauffman, S. (2000). Investigations. Oxford University Press.

Kauffman, S. (2013). Foreword: Evolution beyond Newton, Darwin, and entailing law. In B. G. Henning, & A. C. Scarfe (Eds.), Beyond mechanism: Putting life back into biology (pp. 1-24). Lexington Books.

Khavinson, V., Terekhov, A., Kormilets, D., & Maryanovich, A. (2021). Homology between SARS-CoV-2 and human proteins. Scientific Reports, 11(1), 17199.

Kuramoto, Y., & Nishikawa, I. (1989). Onset of collective rhythms in large populations of coupled oscillators. In H. Takayama (Ed.), Cooperative dynamics in complex physical systems (pp. 300-306). Springer.

Levin, M. (2012). Molecular bioelectricity in developmental biology: New tools and recent discoveries: Control of cell behavior and pattern formation by transmembrane potential gradients. BioEssays, 34(3), 205-217.

Levin, M. (2022). Technological approach to mind everywhere: An experimentally-grounded framework for understanding diverse bodies and minds. Frontiers in Systems Neuroscience, 16, 768201.

Lyons-Weiler, J. (2020). Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Journal of Translational Autoimmunity, 3, 100051.

Markel, K. (2020). Lack of evidence for associative learning in pea plants. Elife, 9, e57614.

Noble, R., & Noble, D. (2018). Harnessing stochasticity: How do organisms make choices? Chaos, 28(10), 106309.

Nunes-Alves, C. (2015). Electrifying long-range signalling. Nature Reviews Microbiology, 13(12), 737-737.

Nunez-Castilla, J., Stebliankin, V., Baral, P., Balbin, C. A., Sobhan, M., Cickovski, T. M., Mondal, A. M., Narasimhan, G., Chapagain, P. P., Mathee, K., & Siltberg-Liberles, J. (2021). Spike mimicry of thrombopoietin may induce thrombocytopenia in COVID-19. BioRxiv, 14(7). https://doi.org/10.3390/v14071415

O'Donoghue, S. I., Schafferhans, A., Sikta, N., Stolte, C., Kaur, S., Ho, B. K., Anderson, S., Procter, J. B., Dallago, C., Bordin, N., Adcock, M., & Rost, B. (2021). SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms. Molecular Systems Biology, 17(9), e10079.

Parker, E. S., Cahill, L., & Mcgaugh, J. L. (2006). A case of unusual autobiographical remembering. Neurocase, 12(1), 35-49.

Pezzulo, G., & Levin, M. (2015). Re-membering the body: Applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs. Integrative Biology, 7(12), 1487-1517.

Pinto, D., Sauer, M. M., Czudnochowski, N., Low, J. S., Tortorici, M. A., Housley, M. P., Noack, J., Walls, A. C., Bowen, J. E., Guarino, B., Rosen, L. E., di Iulio, J., Jerak, J., Kaiser, H., Islam, S., Jaconi, S., Sprugasci, N., Culap, K., Abdelnabi, R., … Veesler, D. (2021). Broad betacoronavirus neutralization by a stem helix-specific human antibody. Science, 373(6559), 1109-1116.

Pismen, L. (2021). Active matter within and around us: From self-propelled particles to flocks and living forms. Springer Nature.

Saigusa, T., Tero, A., Nakagaki, T., & Kuramoto, Y. (2008). Amoebae anticipate periodic events. Physical Review Letters, 100(1), 018101.

Shirakawa, T., & Sato, H. (2013). Construction of a molecular learning network. Journal of Advanced Computational Intelligence, 17, 913-918.

Shirakawa, T., Gunji, Y.-P., & Miyake, Y. (2011). An associative learning experiment using the plasmodium of physarum polycephalum. Nano Communication Networks, 2(2-3), 99-105.

Talwar, G. P., Sharma, N. C., Dubey, S. K., Salahuddin, M., Das, C., Ramakrishnan, S., Kumar, S., & Hingorani, V. (1976). Isoimmunization against human chorionic gonadotropin with conjugates of processed beta-subunit of the hormone and tetanus toxoid. Proceedings of the National Academy of Science, 73(1), 218.

Tammet, D. (2007). Born on a blue day: Inside the extraordinary mind of an autistic savant. Simon and Schuster.

Terhune, D. B., Wudarczyk, O. A., Kochuparampil, P., & Kadosh, C. (2013). Enhanced dimension-specific visual working memory in grapheme - color synesthesia. Cognition, 129(1), 123-137.

Telewski, F. W. (2006). A unified hypothesis of mechanoreception in plants. American Journal of Botany, 93(10), 1466-1476.

Thompson, E. (2009). From autopoiesis to neurophenomenology: A tribute to Francisco Varela. In B. Clarke, & M. Hansen (Eds.), Emergence and embodiment: New essays on second-order systems theory. Duke UP.

Trewavas, A. (2003). Aspects of plant intelligence. Annals of Botany, 92(1), 1-20.

Tseng, A., & Levin, M. (2013). Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Communicative & Integrative Biology, 6(1), 13192-13200.

Tsuda, I., Fujii, H., Tadokoro, S., Yasuoka, T., & Yamaguti, Y. (2004). Chaotic itinerancy as a mechanism of irregular changes between synchronization and desynchronization in a neural network. Journal of Integrative Neuroscience, 03(02), 159-182.

Wheeler, W. (2010). Delectable creatures and the fundamental reality of metaphor: Biosemiotics and animal mind. Biosemiotics, 3(3), 277-287.

Wheeler, W. (2014a) The carrying: Material frames and immaterial meanings. Sign Systems Studies, 42(2/3), 399-411.

Wheeler, W. (2014b). A connoisseur of magical coincidences: Chance, creativity and poiesis from a biosemiotic perspective. Biosemiotics, 7(3), 389-404.

Yeomans, J. M. (2023). Mechanobiology. In Oxford Research Encyclopedia of Physics.

Zhu, X., Ge, X., Li, N., Wu, L. F., Luo, C., Ouyang, Q., Tu, Y., & Chen, G. (2014). Angle sensing in magnetotaxis of Magnetospirillum magneticum AMB-1. Integrative biology, 6(7), 706-713.