Neuroimaging determinants of cognitive impairment in the memory clinic: how important is the vascular burden?
Neurocognitive disorders
Neurodegeneration
Stroke
VBM
VLSM
Vascular lesion
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
received:
10
05
2023
accepted:
15
09
2023
revised:
14
09
2023
medline:
1
10
2023
pubmed:
1
10
2023
entrez:
1
10
2023
Statut:
aheadofprint
Résumé
While neurodegenerative and vascular neurocognitive disorder (NCD) often co-occur, the contribution of vascular lesions, especially stroke lesions identified on MRI, to global cognition in a real-life memory clinic population remains unclear. The main objective of this retrospective study was to determine NCD neuroimaging correlates: the GM atrophy pattern and vascular lesions (especially stroke lesion localization by voxel-based lesion-symptom mapping, VLSM) in a memory clinic. We included 336 patients with mild or major NCD who underwent cerebral MRI and a neuropsychological assessment. The GM atrophy pattern (obtained by voxel-based morphometry, VBM) and the stroke lesion localization (obtained by VLSM) associated with G5 z-score (a global cognitive score), were included as independent variables with other neuroimaging and clinical indices in a stepwise linear regression model. The mean age was 70.3 years and the mean MMSE score 21.3. On MRI, 75 patients had at least one stroke lesion. The G 5 z-score was associated with GM density in the pattern selected by the VBM analysis (R
Identifiants
pubmed: 37777991
doi: 10.1007/s00415-023-12009-1
pii: 10.1007/s00415-023-12009-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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