Design and synthesis of 9-phenanthranilamide derivatives and the study of anti-inflammatory, antioxidant and neuroprotective activities.
Rats
Animals
Antioxidants
/ pharmacology
Lipopolysaccharides
/ pharmacology
Hydrogen Peroxide
/ pharmacology
Anti-Inflammatory Agents
/ pharmacology
Signal Transduction
Neuroprotective Agents
/ pharmacology
Cyclooxygenase 2
/ metabolism
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type II
/ metabolism
Anti-inflammatory
Antioxidant
Ischemic stroke
NF-κB
Neuroprotective
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
23
05
2023
revised:
19
08
2023
accepted:
11
09
2023
medline:
3
11
2023
pubmed:
2
10
2023
entrez:
1
10
2023
Statut:
ppublish
Résumé
Oxidative stress and a series of excessive inflammatory responses are major obstacles to neurological functional recovery after ischemic stroke. In this study, we synthesized several novel 9-phenanthranilamide derivatives and evaluated their anti-inflammatory and antioxidant activities. Among the initially screened compounds, most could strongly inhibi lipopolysaccharide (LPS)-stimulated production of IL-1β, IL-6 and TNF-α in microglial cells. Additionally, compounds 8b, 8q, 8r and 8s significantly inhibited the production of NO, and they also had dose-dependent protective effects on PC12 neuronal cells induced by H
Identifiants
pubmed: 37778192
pii: S0045-2068(23)00522-9
doi: 10.1016/j.bioorg.2023.106861
pii:
doi:
Substances chimiques
Antioxidants
0
Lipopolysaccharides
0
Hydrogen Peroxide
BBX060AN9V
Anti-Inflammatory Agents
0
Neuroprotective Agents
0
Cyclooxygenase 2
EC 1.14.99.1
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type II
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106861Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.