Citrullination and the protein code: crosstalk between post-translational modifications in cancer.
cancer
citrullination
methylation
peptidylarginine deiminase
post-translational modifications
protein
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
ISSN: 1471-2970
Titre abrégé: Philos Trans R Soc Lond B Biol Sci
Pays: England
ID NLM: 7503623
Informations de publication
Date de publication:
20 11 2023
20 11 2023
Historique:
medline:
5
10
2023
pubmed:
2
10
2023
entrez:
1
10
2023
Statut:
ppublish
Résumé
Post-translational modifications (PTMs) of proteins are central to epigenetic regulation and cellular signalling, playing an important role in the pathogenesis and progression of numerous diseases. Growing evidence indicates that protein arginine citrullination, catalysed by peptidylarginine deiminases (PADs), is involved in many aspects of molecular and cell biology and is emerging as a potential druggable target in multiple diseases including cancer. However, we are only just beginning to understand the molecular activities of PADs, and their underlying mechanistic details
Identifiants
pubmed: 37778382
doi: 10.1098/rstb.2022.0243
pmc: PMC10542456
doi:
Substances chimiques
Hydrolases
EC 3.-
Proteins
0
Protein-Arginine Deiminases
EC 3.5.3.15
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20220243Subventions
Organisme : Cancer Research UK
ID : A20776
Pays : United Kingdom
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