Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats.
Apoptosis
Biomarker
Grape seed proanthocyanidin extract
Methylprednisolone
Sperm characteristic
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
13
01
2023
revised:
17
05
2023
accepted:
30
05
2023
pmc-release:
01
10
2024
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of high-dose administration of methylprednisolone (MP) in male rats. A total of 32 adult Wistar male albino rats were divided into four groups: (1) control (CON), received standard food only; (2) MP, received standard food + intraperitoneal injection of 60 mg/kg MP on day 7; (3) GSPE, received standard food + 200 mg/kg/day GSPE; and (4) MP + GSPE, received standard food + 200 mg/kg/day of GSPE + intraperitoneal injection of 60 mg/kg MP on day 7. All animals in the GSPE and GSPE + MP groups were treated once a day by oral gavage for 14 consecutive days. The feed intake of rats in the MP and MP + GSPE groups decreased significantly by 24.14% and 13.52%, respectively (
Identifiants
pubmed: 37779581
doi: 10.1007/s43188-023-00196-y
pii: 196
pmc: PMC10541365
doi:
Types de publication
Journal Article
Langues
eng
Pagination
749-759Informations de copyright
© The Author(s) under exclusive licence to Korean Society of Toxicology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no competing interests to declare that are relevant to the content of this article.
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