Hospitalization Trends and Outcomes of Eosinophilic Esophagitis in the United States: A Decade-Long Nationwide Analysis.
eosinophilic esophagitis
esophageal diseases
hospitalizations
national inpatient sample
trends analysis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
accepted:
28
08
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
Background Eosinophilic esophagitis (EoE) is a chronic antigen-mediated esophageal disease characterized by infiltration of the esophageal mucosa by eosinophils. The prevalence of EoE continues to rise worldwide. However, certain aspects of the epidemiology and pathogenesis remain unclear. Methods This study examined the hospitalization trends of EoE using an extensive inpatient database in the United States, the National (Nationwide) Inpatient Sample (NIS), to identify hospitalizations between 2010 and 2019. We assessed patient demographics as well as hospital-specific variables using the NIS. We obtained the prevalence rate of EoE for each year and used joinpoint regression analysis to obtain trends after adjusting the rate for age and gender. We also sought to characterize the outcomes of these hospitalizations by obtaining the mortality rate, length of stay (LOS), and total hospital charges (THC). Results Of 305 million hospitalizations included in the study, 33,878 were for EoE. The prevalence rate per 100,000 hospitalizations of EoE increased from 6.6 in 2010 to 15.5 in 2019. The annual percentage change obtained from the joinpoint regression analysis was 13.3% from 2010 to 2014 and 7.2% from 2014 to 2019. Most of the hospitalizations were among the male gender and young adults. Almost 95% of hospitalizations across the study period were seen in urban hospitals. We did not notice any significant trend in the mortality rates or length of stay over the study period. The THC increased significantly across the study period. Conclusion There has been an upward trend in the average prevalence rate of EoE over the decade from 2010 to 2019 which almost parallels that of inflammatory bowel disease. This represents a significant burden of disease for a condition that was initially recognized in the late 20th century.
Identifiants
pubmed: 37779798
doi: 10.7759/cureus.44315
pmc: PMC10536399
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e44315Informations de copyright
Copyright © 2023, Kwei-Nsoro et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Clin Invest. 1999 Jun;103(12):1719-27
pubmed: 10377178
N Engl J Med. 2006 Nov 23;355(21):2226-35
pubmed: 17124020
Aliment Pharmacol Ther. 2008 Dec 1;28(11-12):1317-25
pubmed: 18684245
Cureus. 2023 Mar 29;15(3):e36843
pubmed: 37123665
Ann Gastroenterol. 2021 Sep-Oct;34(5):643-650
pubmed: 34475734
Am J Surg Pathol. 1999 Apr;23(4):390-6
pubmed: 10199468
PLoS One. 2013;8(2):e56060
pubmed: 23418510
MMWR Morb Mortal Wkly Rep. 2019 Dec 13;68(49):1134-1138
pubmed: 31830006
Rev Gastroenterol Mex. 2017 Oct - Dec;82(4):328-336
pubmed: 28676192
Breast Cancer Res Treat. 2019 Feb;174(1):237-248
pubmed: 30465155
J Allergy Clin Immunol. 2002 Feb;109(2):363-8
pubmed: 11842310
J Clin Med Res. 2022 Nov;14(11):474-486
pubmed: 36578367
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6681-6
pubmed: 10841566
Gastrointest Endosc Clin N Am. 2008 Jan;18(1):25-32; viii
pubmed: 18061099
Gastrointest Endosc Clin N Am. 2008 Jan;18(1):33-44; viii
pubmed: 18061100
JAMA. 1966 Jul 11;197(2):143-6
pubmed: 5952499
Gastroenterology. 1978 Jun;74(6):1298-1301
pubmed: 648822
Stat Med. 2000 Feb 15;19(3):335-51
pubmed: 10649300
N Engl J Med. 2004 Aug 26;351(9):940-1
pubmed: 15329438
Neurogastroenterol Motil. 2021 Jul;33(7):e14072
pubmed: 33426755
J Pediatr Gastroenterol Nutr. 2011 Jun;52(6):650-61
pubmed: 21593640
J Allergy Clin Immunol. 2015 Jul;136(1):3-13
pubmed: 26145982
J Allergy Clin Immunol. 2005 Feb;115(2):418-9
pubmed: 15696105
Clin Gastroenterol Hepatol. 2014 Apr;12(4):589-96.e1
pubmed: 24035773