Electrooxidative Hofmann Rearrangement of Phthalimides to Access Anthranilate Derivatives.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
received:
04
07
2023
accepted:
04
09
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
A simple and efficient electrooxidative Hofmann rearrangement reaction of phthalimides was developed. Anthranilate derivatives were synthesized in moderate to good yields under green and mild conditions using phthalimides as a rearrangement precursor. This approach not only provides a strategy for synthesizing anthranilates and deuterated anthranilate derivatives with high deuteration efficiency but also realizes efficient conversion at the gram scale. A possible reaction mechanism is proposed.
Identifiants
pubmed: 37779964
doi: 10.1021/acsomega.3c04797
pmc: PMC10536198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35167-35172Informations de copyright
© 2023 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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