Morphological changes of mitochondria-related to apoptosis during postmortem aging of beef muscles.
Apoptosis
Cristae
Fission and fusion
Mitochondrial
Outer membrane
Tenderization
Journal
Food chemistry: X
ISSN: 2590-1575
Titre abrégé: Food Chem X
Pays: Netherlands
ID NLM: 101751436
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
04
05
2023
revised:
08
07
2023
accepted:
20
07
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
This study aimed to investigate how postmortem muscle cells' mitochondria changed in morphology from three aspects: the outer membrane, cristae, and fission/fusion. Atomic force microscopy (AFM) results showed that mitochondria underwent a morphology transformation from normal to swelling and collapse. Meanwhile, the cleavage of OPA1, upregulation of OMA1, downregulation of Mic60 and transmission electron microscope micrographs revealed that mitochondrial cristae ruptured with an aging time extended. Additionally, the increased expressions of Fis1 and Drp1, and the AFM topographic images mutually confirmed mitochondrial fission. These results further proved from the perspective of mitochondrial morphology that the degree of mitochondrial damage increased with the postmortem aging time extended, which was consistent with the results of the release of cytochrome
Identifiants
pubmed: 37780314
doi: 10.1016/j.fochx.2023.100806
pii: S2590-1575(23)00249-3
pmc: PMC10534185
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100806Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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