Research progress on the role of the Wnt signaling pathway in pituitary adenoma.

PA TME Wnt pathway inhibitors Wnt signaling pathway non-coding RNA targeted drugs

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2023
Historique:
received: 04 05 2023
accepted: 28 08 2023
medline: 31 10 2023
pubmed: 2 10 2023
entrez: 2 10 2023
Statut: epublish

Résumé

Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.

Identifiants

pubmed: 37780610
doi: 10.3389/fendo.2023.1216817
pmc: PMC10538627
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1216817

Informations de copyright

Copyright © 2023 Wang, Ma, Zhao, Liu, Ye and Li.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Wencai Wang (W)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Luyao Ma (L)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Yongqiang Zhao (Y)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Menghao Liu (M)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Wei Ye (W)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Xianfeng Li (X)

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

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