Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
received:
19
07
2023
accepted:
21
09
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
A comparative analysis of the micellar and solubilizing properties of two polyethylene glycol (PEG)-based amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge 48/16) and Tetronics® 1304 (T1304), in the presence and absence of salt, was conducted. As there is a dearth of research in this area, the study aims to shed light on the behavior of these two nonionic surfactants and their potential as nanocarriers for solubilizing pharmaceuticals. Various techniques such as cloud point (CP), dynamic light scattering (DLS), small-angle neutron scattering (SANS), Fourier transform infrared spectroscopy (FT-IR), UV spectrophotometry, and high-performance liquid chromatography (HPLC) were employed. The solubility of quercetin (QCT), a flavonoid with anti-inflammatory, antioxidant, and anti-cancer properties, was evaluated and the interaction between QCT and the micellar system was examined. The analysis revealed the occurrence of strong interactions between QCT and surfactant molecules, resulting in enhanced solubility. It was observed that the micellar size and solubilizing ability were significantly improved in the presence of salt, while the CP decreased. Ge 48/16 exhibited superior performance, with a remarkable increase in the solubility of QCT in the presence of salt, suggesting its potential as an effective nanocarrier for a range of pharmaceutics, and yielding better therapeutic outcomes.
Identifiants
pubmed: 37780735
doi: 10.1039/d3ra04844f
pii: d3ra04844f
pmc: PMC10540152
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28590-28601Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
Références
Sci Technol Adv Mater. 2015 May 5;16(3):035001
pubmed: 27877802
Curr Drug Targets. 2011 Jul 1;12(8):1112-30
pubmed: 21443477
AAPS PharmSciTech. 2021 May 24;22(5):161
pubmed: 34031791
Colloids Surf B Biointerfaces. 2018 Oct 1;170:463-469
pubmed: 29960214
J Colloid Interface Sci. 2008 Jan 1;317(1):115-20
pubmed: 17949736
Front Biosci (Elite Ed). 2010 Jan 01;2(2):424-40
pubmed: 20036890
Eur J Pharm Sci. 2005 Oct;26(2):219-30
pubmed: 16087324
J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):235-49
pubmed: 11274893
Pharmaceuticals (Basel). 2022 Jul 12;15(7):
pubmed: 35890153
Dent Mater. 2019 May;35(5):789-796
pubmed: 30827798
J Public Health Afr. 2023 Mar 16;14(Suppl 1):2503
pubmed: 37492533
Drug Dev Ind Pharm. 2018 Apr;44(4):677-686
pubmed: 29164955
Biomed Pharmacother. 2017 Nov;95:894-903
pubmed: 28903185
Adv Drug Deliv Rev. 2006 Dec 30;58(15):1655-70
pubmed: 17125884
Drug Dev Ind Pharm. 2019 Aug;45(8):1361-1368
pubmed: 31096800
Carbohydr Polym. 2023 Feb 15;302:120420
pubmed: 36604082
Eur J Med Chem. 2020 Nov 15;206:112526
pubmed: 32971442
Nanoscale Res Lett. 2021 Aug 18;16(1):132
pubmed: 34406517
Nat Mater. 2013 Nov;12(11):991-1003
pubmed: 24150417
Int J Pharm. 2021 Feb 15;595:120245
pubmed: 33484925
Mol Pharm. 2018 Dec 3;15(12):5741-5753
pubmed: 30351956
Biotechnol Lett. 2021 Mar;43(3):523-535
pubmed: 33534014
Int J Pharm. 2011 Nov 25;420(1):1-10
pubmed: 21884771
Int J Pharm X. 2022 May 10;4:100118
pubmed: 35602759
Int J Pharm. 2020 Aug 30;586:119544
pubmed: 32561309
Toxicol Pathol. 2008 Jan;36(1):43-8
pubmed: 18337220
Polymers (Basel). 2018 Jan 15;10(1):
pubmed: 30966111
Nanomedicine (Lond). 2010 Apr;5(3):485-505
pubmed: 20394539
Expert Opin Drug Deliv. 2018 Nov;15(11):1085-1104
pubmed: 30259762
Drug Deliv. 2018 Nov;25(1):1694-1705
pubmed: 30394120
Mol Pharm. 2011 Aug 1;8(4):1152-64
pubmed: 21591727
J Pharm Pharm Sci. 2005 Jul 08;8(2):147-65
pubmed: 16124926
Environ Health Perspect. 1995 Apr;103(4):358-64
pubmed: 7607136
Int J Pharm. 2020 Mar 30;578:119057
pubmed: 31991188
Pharmaceutics. 2022 Sep 23;14(10):
pubmed: 36297459
Mol Pharm. 2019 Dec 2;16(12):4757-4774
pubmed: 31633939
Phytomedicine. 2015 Nov 15;22(12):1103-11
pubmed: 26547533
Biomacromolecules. 2003 Jul-Aug;4(4):864-8
pubmed: 12857066
Pharm Res. 2007 Jan;24(1):1-16
pubmed: 17109211
J Control Release. 2001 Jun 15;73(2-3):137-72
pubmed: 11516494
Pharmaceuticals (Basel). 2021 Dec 23;15(1):
pubmed: 35056072
AAPS PharmSciTech. 2021 Jun 15;22(5):182
pubmed: 34129146
Nanotechnology. 2022 Jan 21;33(15):
pubmed: 34959230
Adv Pharm Bull. 2020 Jul;10(3):359-369
pubmed: 32665894
Colloids Surf B Biointerfaces. 2012 Jun 1;94:259-65
pubmed: 22386863
Pharmaceutics. 2020 Jun 12;12(6):
pubmed: 32545643
Adv Drug Deliv Rev. 2001 Mar 23;47(1):113-31
pubmed: 11251249