Association of folic acid dosage with circulating unmetabolized folic acid in Chinese adults with H-type hypertension: a multicenter, double-blind, randomized controlled trial.

H-type hypertension dosage folic acid safety unmetabolized folic acid

Journal

Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264

Informations de publication

Date de publication:
2023
Historique:
received: 22 03 2023
accepted: 29 08 2023
medline: 2 10 2023
pubmed: 2 10 2023
entrez: 2 10 2023
Statut: epublish

Résumé

There is growing concern regarding elevated levels of circulating unmetabolized folic acid (UMFA) due to excessive intake of folic acid (FA). However, no randomized clinical trial has been conducted to examine the FA-UMFA dose-response relationship. This study aimed to investigate the FA-UMFA dose-response relationship in Chinese adults with hypertension and elevated homocysteine (H-type hypertension), a population with clear clinical indication for FA treatment. The data for this study were derived from a randomized, double-blind, multicenter clinical trial of 8 FA dosages on efficacy of homocysteine (Hcy) lowering. The parent trial had three 3 stages: screening period (2-10 days), run-in period (0-2 weeks, baseline visit), and double-blind treatment period (8 weeks) with follow-up visits at the end of the 2nd, 4th, 6th, and 8th weeks of treatment. Participants were randomly assigned to 8 treatment groups corresponding to FA dosages of 0, 0.4, 0.6, 0.8, 1.2, 1.6, 2.0 mg to 2.4 mg. This study included 1,567 Chinese adults aged ≥45 years with H-type hypertension. There was a positive but non-linear association between FA supplementation and UMFA levels in the dosage range of 0 mg to 2.4 mg. In the regression analysis, the coefficients for the linear and quadratic terms of FA dosage were both statistically significant ( In Chinese adults with H-type hypertension, this study showed a positive, non-linear, dosage-response relationship between FA supplementation ranging from 0 to 2.4 mg and circulating UMFA levels. It revealed that 0.8 mg FA is an optimal dosage in terms of balancing efficacy (increasing 5-MTHF and lowering Hcy) while minimizing undesirable elevation of UMFA. https://clinicaltrials.gov/ct2/show/NCT03472508?term=NCT03472508&draw=2&rank=1, identifier NCT03472508.

Sections du résumé

Background UNASSIGNED
There is growing concern regarding elevated levels of circulating unmetabolized folic acid (UMFA) due to excessive intake of folic acid (FA). However, no randomized clinical trial has been conducted to examine the FA-UMFA dose-response relationship.
Objective UNASSIGNED
This study aimed to investigate the FA-UMFA dose-response relationship in Chinese adults with hypertension and elevated homocysteine (H-type hypertension), a population with clear clinical indication for FA treatment.
Methods UNASSIGNED
The data for this study were derived from a randomized, double-blind, multicenter clinical trial of 8 FA dosages on efficacy of homocysteine (Hcy) lowering. The parent trial had three 3 stages: screening period (2-10 days), run-in period (0-2 weeks, baseline visit), and double-blind treatment period (8 weeks) with follow-up visits at the end of the 2nd, 4th, 6th, and 8th weeks of treatment. Participants were randomly assigned to 8 treatment groups corresponding to FA dosages of 0, 0.4, 0.6, 0.8, 1.2, 1.6, 2.0 mg to 2.4 mg.
Results UNASSIGNED
This study included 1,567 Chinese adults aged ≥45 years with H-type hypertension. There was a positive but non-linear association between FA supplementation and UMFA levels in the dosage range of 0 mg to 2.4 mg. In the regression analysis, the coefficients for the linear and quadratic terms of FA dosage were both statistically significant (
Conclusion UNASSIGNED
In Chinese adults with H-type hypertension, this study showed a positive, non-linear, dosage-response relationship between FA supplementation ranging from 0 to 2.4 mg and circulating UMFA levels. It revealed that 0.8 mg FA is an optimal dosage in terms of balancing efficacy (increasing 5-MTHF and lowering Hcy) while minimizing undesirable elevation of UMFA.
Clinical trial registration UNASSIGNED
https://clinicaltrials.gov/ct2/show/NCT03472508?term=NCT03472508&draw=2&rank=1, identifier NCT03472508.

Identifiants

pubmed: 37781132
doi: 10.3389/fnut.2023.1191610
pmc: PMC10538967
doi:

Banques de données

ClinicalTrials.gov
['NCT03472508']

Types de publication

Journal Article

Langues

eng

Pagination

1191610

Informations de copyright

Copyright © 2023 Chen, Tang, Song, Wang, Qin, Zhang, Wei, Xu, Zhou, He, Liu, Siddiqi, Huang, Cheng, Tang, Duan, Zhou, Jiang and Li.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Ping Chen (P)

College of Pharmacy, Jinan University, Guangzhou, China.

Linlin Tang (L)

State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, China.

Yun Song (Y)

Institute of Biomedicine, Anhui Medical University, Hefei, China.

Binyan Wang (B)

Institute of Biomedicine, Anhui Medical University, Hefei, China.

Xianhui Qin (X)

National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Nan Zhang (N)

National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Yaping Wei (Y)

Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.

Xiping Xu (X)

Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.

Ziyi Zhou (Z)

Shenzhen Evergreen Medical Institute, Shenzhen, China.

Qiangqiang He (Q)

Shenzhen Evergreen Medical Institute, Shenzhen, China.

Lishun Liu (L)

Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.

Sultan Mehmood Siddiqi (SM)

Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.

Xiao Huang (X)

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Xiaoshu Cheng (X)

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Genfu Tang (G)

School of Health Administration, Anhui Medical University, Hefei, China.

Yong Duan (Y)

Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

Houqing Zhou (H)

Department of Clinical Laboratory, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, China.

Jie Jiang (J)

College of Pharmacy, Jinan University, Guangzhou, China.

Sha Li (S)

College of Pharmacy, Jinan University, Guangzhou, China.

Classifications MeSH