Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity.
amorphous calcium phosphate
calcium
isotope distribution
lithium
lithium bioactivity
mitochondria
mitochondrial calcium
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
04
2023
accepted:
21
08
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
Lithium is commonly prescribed as a mood stabilizer in a variety of mental health conditions, yet its molecular mode of action is incompletely understood. Many cellular events associated with lithium appear tied to mitochondrial function. Further, recent evidence suggests that lithium bioactivities are isotope specific. Here we focus on lithium effects related to mitochondrial calcium handling. Lithium protected against calcium-induced permeability transition and decreased the calcium capacity of liver mitochondria at a clinically relevant concentration. In contrast, brain mitochondrial calcium capacity was increased by lithium. Surprisingly,
Identifiants
pubmed: 37781224
doi: 10.3389/fphys.2023.1200119
pii: 1200119
pmc: PMC10540846
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1200119Informations de copyright
Copyright © 2023 Deline, Straub, Patel, Subba, Grashei, van Heijster, Pirkwieser, Somoza, Livingstone, Beazely, Kendall, Gingras, Leonenko, Höschen, Harrington, Kuellmer, Bian, Schilling, Fisher, Helgeson and Fromme.
Déclaration de conflit d'intérêts
MF holds a US patent (US 9,044,418 B2) issued on 2 June 2015 for clinical uses of isotope-modified lithium formulations entitled, “Treatment for depression and other mental conditions with synthetic isotope-modified lithium”. This study was in part funded by a research grant by IONIS Pharmaceuticals, United States, to MF, TF, MiG, ZL, and MH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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