Innate immune response restarts adaptive immune response in tumors.
DNA sensing
RNA sensing
crosstalk
glioblastoma
type I interferon
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
07
2023
accepted:
25
08
2023
medline:
31
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
The imbalance of immune response plays a crucial role in the development of diseases, including glioblastoma. It is essential to comprehend how the innate immune system detects tumors and pathogens. Endosomal and cytoplasmic sensors can identify diverse cancer cell antigens, triggering the production of type I interferon and pro-inflammatory cytokines. This, in turn, stimulates interferon stimulating genes, enhancing the presentation of cancer antigens, and promoting T cell recognition and destruction of cancer cells. While RNA and DNA sensing of tumors and pathogens typically involve different receptors and adapters, their interaction can activate adaptive immune response mechanisms. This review highlights the similarity in RNA and DNA sensing mechanisms in the innate immunity of both tumors and pathogens. The aim is to enhance the anti-tumor innate immune response, identify regions of the tumor that are not responsive to treatment, and explore new targets to improve the response to conventional tumor therapy and immunotherapy.
Identifiants
pubmed: 37781382
doi: 10.3389/fimmu.2023.1260705
pmc: PMC10538570
doi:
Substances chimiques
DNA
9007-49-2
Interferon Type I
0
RNA
63231-63-0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1260705Informations de copyright
Copyright © 2023 Li, Zhang, Li, Liu, Yuan and Pan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell. 2021 Oct 14;184(21):5338-5356.e21
pubmed: 34624222
Annu Rev Biophys. 2023 May 9;52:207-228
pubmed: 36626767
Nat Med. 2014 Nov;20(11):1301-9
pubmed: 25344738
Cell. 2015 Sep 10;162(6):1229-41
pubmed: 26321679
J Immunother Cancer. 2019 Jul 19;7(1):190
pubmed: 31324218
JAMA. 2013 Oct 9;310(14):1473-81
pubmed: 24104372
Cell. 2004 Aug 6;118(3):285-96
pubmed: 15294155
PLoS Pathog. 2022 Aug 8;18(8):e1010748
pubmed: 35939517
Science. 2003 Aug 1;301(5633):640-3
pubmed: 12855817
Nat Commun. 2017 Sep 11;8(1):511
pubmed: 28894104
Nucleic Acids Res. 2014 Mar;42(5):3228-45
pubmed: 24371270
Trends Immunol. 2011 Mar;32(3):104-9
pubmed: 21269878
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4592-7
pubmed: 22393002
Cancer Immunol Immunother. 2019 Jul;68(7):1195-1209
pubmed: 31177329
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
pubmed: 26371324
Cell Death Differ. 2019 Jan;26(2):332-347
pubmed: 29786074
Cell. 2017 Jun 29;170(1):142-157.e19
pubmed: 28648661
Hepatology. 2014 Apr;59(4):1415-26
pubmed: 24002931
Nat Rev Drug Discov. 2017 Sep 29;16(10):669
pubmed: 28959944
Immunity. 2013 Sep 19;39(3):432-41
pubmed: 24054327
Nat Med. 2018 Aug;24(8):1143-1150
pubmed: 30038220
Cancer Cell. 2014 Jan 13;25(1):37-48
pubmed: 24434209
J Clin Invest. 2008 Mar;118(3):1165-75
pubmed: 18259609
Cell. 2014 Feb 27;156(5):1045-59
pubmed: 24581500
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Front Immunol. 2019 May 31;10:1209
pubmed: 31214180
Virology. 2012 Apr 10;425(2):71-81
pubmed: 22305621
J Exp Med. 2005 Mar 21;201(6):915-23
pubmed: 15767370
Nat Med. 2018 Jul;24(7):986-993
pubmed: 29942092
Cancer Lett. 2011 Jun 28;305(2):250-62
pubmed: 21093147
J Clin Invest. 2015 Sep;125(9):3365-76
pubmed: 26325033
Cell. 2016 Jan 28;164(3):564-78
pubmed: 26824662
Transl Oncol. 2017 Aug;10(4):491-500
pubmed: 28550769
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3930-3935
pubmed: 29581256
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
J Invest Dermatol. 2006 Jan;126(1):32-41
pubmed: 16417215
JCI Insight. 2016 Dec 8;1(20):e89289
pubmed: 27942588
Immunity. 2010 Aug 27;33(2):229-40
pubmed: 20727791
Nat Rev Immunol. 2013 Apr;13(4):227-42
pubmed: 23470321
Blood. 2007 Feb 15;109(4):1574-83
pubmed: 17038528
Blood. 2008 Feb 15;111(4):2101-11
pubmed: 18042802
Front Immunol. 2017 Sep 29;8:1221
pubmed: 29033940
Physiology (Bethesda). 2020 Mar 1;35(2):112-124
pubmed: 32027562
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82
pubmed: 20457902
Immunity. 2011 Feb 25;34(2):213-23
pubmed: 21349431
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
JCI Insight. 2019 Aug 8;4(15):
pubmed: 31391334
Br J Cancer. 2013 Aug 20;109(4):1031-9
pubmed: 23868000
Science. 2016 Apr 22;352(6284):459-63
pubmed: 27102484
Nat Immunol. 2020 Oct;21(10):1256-1266
pubmed: 32839610
Nat Immunol. 2016 Apr;17(4):422-32
pubmed: 26950239
J Clin Oncol. 2015 Jun 10;33(17):1974-82
pubmed: 25605845
Cell. 2017 Nov 2;171(4):809-823.e13
pubmed: 29056340
J Leukoc Biol. 2013 Mar;93(3):343-52
pubmed: 23136258
Nature. 2014 Sep 25;513(7519):559-63
pubmed: 25043024
J Exp Med. 2018 May 7;215(5):1287-1299
pubmed: 29622565
J Exp Med. 2015 Jun 29;212(7):1125-37
pubmed: 26034050
Cancer Res. 2020 Apr 15;80(8):1707-1719
pubmed: 32060149
Nat Rev Immunol. 2021 Dec;21(12):769-784
pubmed: 33879873
J Clin Invest. 2011 Apr;121(4):1361-72
pubmed: 21436588
Immunity. 2013 May 23;38(5):870-80
pubmed: 23706668
Mol Ther. 2017 Mar 1;25(3):580-592
pubmed: 28187946
Nat Commun. 2014 Oct 10;5:5166
pubmed: 25300616
Cancer Immunol Res. 2019 May;7(5):759-772
pubmed: 30890531
Nature. 2017 Jul 13;547(7662):222-226
pubmed: 28678784
PLoS Pathog. 2014 Apr 17;10(4):e1004081
pubmed: 24743923
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21635-40
pubmed: 21118981
Nat Immunol. 2013 Nov;14(11):1155-65
pubmed: 24056747
J Immunol. 2005 Sep 1;175(5):2851-8
pubmed: 16116171
J Clin Invest. 2016 Jun 1;126(6):2123-38
pubmed: 27111235
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Nat Rev Immunol. 2005 Oct;5(10):749-59
pubmed: 16175180
Viruses. 2023 Jan 25;15(2):
pubmed: 36851555
Cell. 2006 Jan 27;124(2):263-6
pubmed: 16439202
Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:168-80
pubmed: 25795119
Nature. 2017 Sep 21;549(7672):394-398
pubmed: 28902841
Neuro Oncol. 2015 Aug;17(8):1064-75
pubmed: 25355681
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5256-61
pubmed: 17875753
Biochem Biophys Res Commun. 2016 Sep 30;478(4):1764-71
pubmed: 27608599
Cancer Res. 2013 Jun 15;73(12):3566-77
pubmed: 23576561
Cancer Immunol Res. 2014 Dec;2(12):1199-208
pubmed: 25300859
Nat Rev Immunol. 2015 Jul;15(7):405-14
pubmed: 26027717
Nat Immunol. 2004 Oct;5(10):987-95
pubmed: 15454922
Nat Immunol. 2011 Sep 04;12(10):959-65
pubmed: 21892174
Cell Rep. 2019 Oct 29;29(5):1236-1248.e7
pubmed: 31665636
Trends Mol Med. 2020 Mar;26(3):311-323
pubmed: 31699497
Nature. 2009 Jun 4;459(7247):712-6
pubmed: 19412163
J Exp Clin Cancer Res. 2010 Jul 10;29:92
pubmed: 20618976
Cancer Res. 2011 Apr 1;71(7):2488-96
pubmed: 21300764
Cancer Res. 2020 Feb 1;80(3):471-483
pubmed: 31767627
EMBO J. 2014 Dec 17;33(24):2937-46
pubmed: 25425575
Annu Rev Immunol. 2017 Apr 26;35:313-336
pubmed: 28142323
Cancer Res. 2012 Oct 15;72(20):5188-97
pubmed: 22836755
Nature. 2019 Mar;567(7747):262-266
pubmed: 30842662
J Immunol. 2015 Sep 1;195(5):1939-43
pubmed: 26223655
Hepatology. 2013 Sep;58(3):940-9
pubmed: 22577054
Nature. 2018 Jun;558(7709):307-312
pubmed: 29849141
J Immunol. 2018 Apr 15;200(8):2748-2756
pubmed: 29540580
Oncogene. 2008 Jan 7;27(2):244-52
pubmed: 18176606
Cancer Cell. 2020 Oct 12;38(4):454-472
pubmed: 32822573
Clin Cancer Res. 2021 Oct 15;27(20):5528-5535
pubmed: 34433652
J Immunol. 2014 Oct 15;193(8):4254-60
pubmed: 25217157
Trends Pharmacol Sci. 2016 Mar;37(3):220-230
pubmed: 26705086
Cell. 2012 Aug 17;150(4):803-15
pubmed: 22901810
Nat Immunol. 2021 Jan;22(1):53-66
pubmed: 33230330
JCI Insight. 2018 Sep 20;3(18):
pubmed: 30232280
Cell Rep. 2018 May 01;23(5):1435-1447
pubmed: 29719256
Science. 2019 Mar 8;363(6431):
pubmed: 30846571
Nat Commun. 2018 Nov 19;9(1):4841
pubmed: 30451863
Mol Cancer Ther. 2006 Jun;5(6):1585-92
pubmed: 16818518
Immunity. 2014 Nov 20;41(5):830-42
pubmed: 25517615
Cancer Res. 2018 Aug 15;78(16):4692-4703
pubmed: 29967261
Nat Rev Cancer. 2013 Aug;13(8):525-41
pubmed: 23880905
Nat Rev Drug Discov. 2018 Apr;17(4):261-279
pubmed: 29326426
J Immunol. 2011 Jun 15;186(12):7187-94
pubmed: 21543645
Clin Cancer Res. 2020 Sep 1;26(17):4699-4712
pubmed: 32554515
Oncoimmunology. 2018 Aug 6;7(10):e1488565
pubmed: 30288356
Oncoimmunology. 2020 Jun 16;9(1):1777624
pubmed: 32934881
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
J Immunol. 2008 Oct 15;181(8):5396-404
pubmed: 18832696
Nat Immunol. 2013 Nov;14(11):1173-82
pubmed: 24076634
Cell Host Microbe. 2014 Feb 12;15(2):228-38
pubmed: 24528868
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
Nat Immunol. 2016 Sep 20;17(10):1142-9
pubmed: 27648547
Nat Immunol. 2018 Jan;19(1):53-62
pubmed: 29180807
Nat Commun. 2017 Sep 5;8(1):427
pubmed: 28874664
Nat Med. 2011 Sep 18;17(10):1290-7
pubmed: 21926977
Front Immunol. 2019 Feb 08;10:168
pubmed: 30800125
PLoS Pathog. 2010 May 27;6(5):e1000924
pubmed: 20523894
Nat Rev Drug Discov. 2019 Mar;18(3):197-218
pubmed: 30610226
Nat Immunol. 2009 Oct;10(10):1073-80
pubmed: 19701189
Science. 2013 Feb 15;339(6121):826-30
pubmed: 23258412
Cell Death Differ. 2017 Apr;24(4):615-625
pubmed: 28060376
J Immunol. 2010 Feb 1;184(3):1191-9
pubmed: 20026746
Clin Cancer Res. 2015 Nov 1;21(21):4774-9
pubmed: 26373573
Int J Cancer. 2006 Dec 15;119(12):2784-94
pubmed: 17019715
Cancer Res. 2017 Aug 1;77(15):4135-4145
pubmed: 28615225
Cancer Sci. 2018 Mar;109(3):531-541
pubmed: 29285841
Hum Vaccin Immunother. 2014;10(11):3270-85
pubmed: 25625930
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13
pubmed: 26607445
Science. 2018 Jan 12;359(6372):177-186
pubmed: 29326266
Clin Cancer Res. 2020 Aug 1;26(15):3901-3907
pubmed: 32332013
Trends Immunol. 2017 Feb;38(2):94-103
pubmed: 27939451
Exp Hematol Oncol. 2013 May 20;2(1):15
pubmed: 23687996
Nature. 2011 Jan 20;469(7330):323-35
pubmed: 21248839
Oncotarget. 2021 Feb 16;12(4):292-303
pubmed: 33659041
Nat Commun. 2021 Apr 19;12(1):2327
pubmed: 33875663
Cancer Cell. 2018 May 14;33(5):862-873.e5
pubmed: 29706455
Nat Med. 2019 Jan;25(1):95-102
pubmed: 30559422
Biomed Pharmacother. 2020 May;125:109984
pubmed: 32066042
Science. 2015 Oct 30;350(6260):568-71
pubmed: 26405230
Oncotarget. 2018 Nov 9;9(88):35807-35808
pubmed: 30533195
J Immunother Cancer. 2017 Dec 19;5(1):101
pubmed: 29254508
Science. 2015 Nov 13;350(6262):826-30
pubmed: 26494172
Mol Ther Nucleic Acids. 2016 Jun 21;5(6):e326
pubmed: 27327138
Immunity. 2011 May 27;34(5):665-79
pubmed: 21616436
Cell. 2020 Mar 19;180(6):1115-1129.e13
pubmed: 32200799
J Immunol. 2011 Nov 15;187(10):5221-32
pubmed: 22013128
Nature. 2013 Jun 27;498(7455):506-10
pubmed: 23728300
Cell Immunol. 2017 Dec;322:1-14
pubmed: 29079339
Nat Struct Mol Biol. 2010 Jun;17(6):666-72
pubmed: 20495563
Mol Ther. 2017 Sep 6;25(9):2214-2224
pubmed: 28602436
Cancer Cell. 2014 Jan 13;25(1):49-63
pubmed: 24360797
Clin Cancer Res. 2017 May 1;23(9):2255-2266
pubmed: 27815355
Cell Cycle. 2023 Jan;22(1):38-56
pubmed: 35946607
Microorganisms. 2021 May 30;9(6):
pubmed: 34070716
Leukemia. 2018 May;32(5):1157-1167
pubmed: 29479065
Trends Mol Med. 2019 May;25(5):382-394
pubmed: 30853173
Nature. 2018 Jul;559(7713):269-273
pubmed: 29973723
Clin Cancer Res. 2018 Jul 1;24(13):3036-3045
pubmed: 29599411
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
EMBO J. 2018 Apr 13;37(8):
pubmed: 29496741
Nat Immunol. 2009 Oct;10(10):1065-72
pubmed: 19609254
J Virol. 2009 Oct;83(20):10761-9
pubmed: 19656871
Sci Transl Med. 2013 Aug 28;5(200):200ra116
pubmed: 23986400
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15
pubmed: 26199418
Immunity. 2010 Mar 26;32(3):379-91
pubmed: 20303296
Nature. 2023 Jun;618(7963):144-150
pubmed: 37165196
Cell Death Differ. 2016 Jan;23(1):76-88
pubmed: 26024392
Clin Cancer Res. 2015 Feb 15;21(4):687-92
pubmed: 25501578
J Immunol. 2015 Aug 1;195(3):1100-11
pubmed: 26085680
Nat Immunol. 2013 Oct;14(10):1014-22
pubmed: 24048123
J Immunol. 2014 Dec 15;193(12):6124-34
pubmed: 25385820
Nat Microbiol. 2017 Mar 27;2:17037
pubmed: 28346446
Scand J Immunol. 2009 Jul;70(1):18-24
pubmed: 19522763
Nat Immunol. 2020 Oct;21(10):1160-1171
pubmed: 32747819
Nat Cell Biol. 2014 Jan;16(1):55-65
pubmed: 24316671
J Virol. 2006 May;80(10):5059-64
pubmed: 16641297
Nat Rev Cancer. 2023 Apr;23(4):238-257
pubmed: 36792751
Mol Cancer. 2021 Feb 25;20(1):41
pubmed: 33632261
Br J Cancer. 2015 Jun 9;112(12):1911-20
pubmed: 26057582
Crit Rev Oncol Hematol. 2022 Oct;178:103780
pubmed: 35953012
Cell Res. 2017 Jan;27(1):154-157
pubmed: 27910851
J Clin Med. 2017 Nov 29;6(12):
pubmed: 29186062