Association of the severity of colic in horses with oxidative stress biomarkers, acute-phase proteins, and certain trace elements.
acute-phase proteins
clinical signs
colic
oxidative stress
Journal
Journal of equine science
ISSN: 1340-3516
Titre abrégé: J Equine Sci
Pays: Japan
ID NLM: 9503751
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
05
02
2023
accepted:
09
05
2023
medline:
2
10
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
ppublish
Résumé
Sixty-one horses were enrolled in this study and divided into 3 different groups according to their severity of colic (heart rate, oral mucous membrane color, and abdominal distention): a strangulating colic (SC) group (n=21), non-strangulating colic (NC) group (n=20), and control group (n=20) consisting of randomly selected normal horses without signs of colic. The serum concentrations of haptoglobin, tumor necrosis factor-α (TNFα), nitric oxide (NO), malondialdehyde (MDA), zinc, iron, and copper were evaluated in all horses. The average concentration of TNFα in the SC group was higher than that in the control group (P<0.001). The TNFα concentration was higher in the NC group compared with the control group (P<0.001). Furthermore, the average concentration of TNFα tended to be higher in the SC group compared with the NC group (P=0.052). The average concentration of haptoglobin in the SC group was higher than that in the control group (P<0.001). The average concentration of NO was higher in the SC group compared with the NC group. (P=0.016) The average concentration of MDA was higher in the SC group compared with the control group (P=0.042). Furthermore, the concentration of MDA was higher in the SC group compared with the NC group (P=0.048). TNFα in horses with signs of colic may be a reliable indicator of prognosis and the severity of clinical signs. The haptoglobin concentration may be a useful marker in cases where animals are referred to clinicians a few days after the onset of colic. The concentrations of MDA and NO should be interpreted with caution.
Identifiants
pubmed: 37781567
doi: 10.1294/jes.34.73
pii: 2304
pmc: PMC10534060
doi:
Types de publication
Journal Article
Langues
eng
Pagination
73-81Informations de copyright
©2023 The Japanese Society of Equine Science.
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