Convergent Total Synthesis of (-)-Cyclopamine.

Cyclization Alkenes Veratrum Alkaloids Stereoisomerism

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
11 10 2023
Historique:
pmc-release: 11 10 2024
medline: 1 11 2023
pubmed: 2 10 2023
entrez: 2 10 2023
Statut: ppublish

Résumé

A concise and enantioselective total synthesis of the

Identifiants

DOI: 10.1021/jacs.3c09085 PMID: 37782691 PMC: PMC10696607
pubmed: 37782691
doi: 10.1021/jacs.3c09085
pmc: PMC10696607
mid: NIHMS1946515
doi:

Substances chimiques

cyclopamine ZH658AJ192
Alkenes 0
Veratrum Alkaloids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

21760-21765

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118176
Pays : United States

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Auteurs

Manolis Sofiadis (M)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Dongmin Xu (D)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Anthony J Rodriguez (AJ)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Benedikt Nissl (B)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Sebastian Clementson (S)

Research and Early Development, LEO Pharma A/S, 2750 Ballerup, Denmark.

Nadia Nasser Petersen (NN)

Research and Early Development, LEO Pharma A/S, 2750 Ballerup, Denmark.

Phil S Baran (PS)

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
ORCID: 0000-0001-9193-9053

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Cyclisation › Convergent Total Synthesis of (-)-Cyclopamine.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcènes › Convergent Total Synthesis of (-)-Cyclopamine.
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes de Veratrum › Convergent Total Synthesis of (-)-Cyclopamine.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Convergent Total Synthesis of (-)-Cyclopamine.