Regeneration of injured articular cartilage using the recombinant human amelogenin protein.
Journal
Bone & joint research
ISSN: 2046-3758
Titre abrégé: Bone Joint Res
Pays: England
ID NLM: 101586057
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
medline:
3
10
2023
pubmed:
3
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
Cartilage injuries rarely heal spontaneously and often require surgical intervention, leading to the formation of biomechanically inferior fibrous tissue. This study aimed to evaluate the possible effect of amelogenin on the healing process of a large osteochondral injury (OCI) in a rat model. A reproducible large OCI was created in the right leg femoral trochlea of 93 rats. The OCIs were treated with 0.1, 0.5, 1.0, 2.5, or 5.0 μg/μl recombinant human amelogenin protein (rHAM A total of 12 weeks after treatment, 0.5 μg/μl rHAM We found that 0.5 μg/μl rHAM
Identifiants
pubmed: 37783468
doi: 10.1302/2046-3758.1210.BJR-2023-0019.R1
pii: BJR-2023-0019.R1
pmc: PMC10545453
doi:
Types de publication
Journal Article
Langues
eng
Pagination
615-623Informations de copyright
© 2023 Author(s) et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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