NAD


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
02 10 2023
Historique:
received: 29 03 2023
accepted: 30 08 2023
medline: 4 10 2023
pubmed: 3 10 2023
entrez: 2 10 2023
Statut: epublish

Résumé

Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic level. We found the NAD

Identifiants

pubmed: 37783679
doi: 10.1038/s41467-023-41372-w
pii: 10.1038/s41467-023-41372-w
pmc: PMC10545792
doi:

Substances chimiques

NAD 0U46U6E8UK
Cytokines 0
Adenosine Triphosphate 8L70Q75FXE
NMNAT1 protein, human EC 2.7.7.1
Nicotinamide-Nucleotide Adenylyltransferase EC 2.7.7.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5818

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Björn Klabunde (B)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

André Wesener (A)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

Wilhelm Bertrams (W)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

Isabell Beinborn (I)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

Nicole Paczia (N)

Core Facility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.

Kristin Surmann (K)

Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Sascha Blankenburg (S)

Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Jochen Wilhelm (J)

Institute for Lung Health (ILH), Giessen, Germany.
Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-Universität Giessen, German Center for Lung Research (DZL), Giessen, Germany.

Javier Serrania (J)

Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, Marburg, Germany.

Kèvin Knoops (K)

Microscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

Eslam M Elsayed (EM)

Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, Marburg, Germany.
Department of Biology, Philipps-Universität Marburg, Marburg, Germany.
Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Katrin Laakmann (K)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

Anna Lena Jung (AL)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.
Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-Universität Marburg, Marburg, Germany.

Andreas Kirschbaum (A)

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Gießen and Marburg (UKGM), Marburg, Germany.

Sven Hammerschmidt (S)

Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.

Belal Alshaar (B)

Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Nicolas Gisch (N)

Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Mobarak Abu Mraheil (M)

Institute for Medical Microbiology, Justus-Liebig Universität Giessen, Giessen, Germany.

Anke Becker (A)

Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, Marburg, Germany.

Uwe Völker (U)

Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Evelyn Vollmeister (E)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany.

Birke J Benedikter (BJ)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany. b.benedikter@maastrichtuniversity.nl.
University Eye Clinic Maastricht, Maastricht University Medical Center (MUMC+), School for Mental Health and Neuroscience, Maastricht University, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. b.benedikter@maastrichtuniversity.nl.

Bernd Schmeck (B)

Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps-Universität Marburg, Marburg, Germany. schmeck@staff.uni-marburg.de.
Institute for Lung Health (ILH), Giessen, Germany. schmeck@staff.uni-marburg.de.
Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universität Marburg, Marburg, Germany. schmeck@staff.uni-marburg.de.
Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-Universität Marburg, Marburg, Germany. schmeck@staff.uni-marburg.de.
Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Marburg, Philipps-Universität Marburg, Marburg, Germany. schmeck@staff.uni-marburg.de.
Member of the German Center for Infectious Disease Research (DZIF), Marburg, Germany. schmeck@staff.uni-marburg.de.

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Classifications MeSH