Supramaximal resection based on en-bloc technique reduces tumor burden and prolongs survival in primary supratentorial lobar glioblastoma.
Clinical outcomes
En-bloc technique
Glioblastoma
Membranous structures
Supramaximal resection
Journal
Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
20
06
2023
accepted:
17
07
2023
medline:
31
10
2023
pubmed:
3
10
2023
entrez:
2
10
2023
Statut:
ppublish
Résumé
Resection beyond the contrast-enhanced zone contributed to reduce tumor burden and prolong survival in glioblastomas. The optimal extent of resection (EOR) and how to achieve it are worthy of continuous investigation for obtaining a satisfactory balance between maximal resection and the preservation of neurological function. A total of 340 adult supratentorial lobar glioblastomas (included astrocytoma, WHO 4, IDH mutation and glioblastoma) were retrospectively evaluated. The clinical data, EOR, technique of resection, postoperative complications, overall survival (OS) and progression-free survival (PFS) were assessed by univariate, multivariate and propensity score matched analysis. Histological staining was performed to comprehend the effect of the membranous structures and the cell distribution in tumoral and peritumoral regions. Supramaximal resection (SMR) was confirmed as resection with 100% EOR Applying en-bloc technique and achieving SMR, which could reduce tumor burden and did not increase additional complications, both had remarkedly positive effects on clinical outcomes in patients with primary supratentorial lobar glioblastomas.
Identifiants
pubmed: 37783878
doi: 10.1007/s11060-023-04399-z
pii: 10.1007/s11060-023-04399-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
557-568Subventions
Organisme : National Natural Science Foundation of China
ID : 81702473
Organisme : National Natural Science Foundation of China
ID : 82102100
Organisme : Natural Science Foundation of Guangdong Province
ID : 2114050002642
Organisme : Clinical Research Program of Nanfang Hospital
ID : 2020CR017
Organisme : President Fund of Nanfang Hospital
ID : 2018Z015
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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