Roles of Twist1 in lipid and glucose metabolism.
Adipose tissue
Fatty acid oxidation
Glucose metabolism
Lipid metabolism
Twist1
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
02 10 2023
02 10 2023
Historique:
received:
10
06
2023
accepted:
09
08
2023
medline:
4
10
2023
pubmed:
3
10
2023
entrez:
2
10
2023
Statut:
epublish
Résumé
The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcriptional factor Twist1 has been associated with not only the embryonic development, cancer, and fibrotic diseases, but also the regulation of lipid and glucose metabolism. In this review, we will discuss the roles and mechanisms of Twist1 in the obesity-associated white adipose tissue inflammation and insulin resistance, brown adipose tissue metabolism, fatty acid oxidation, and glucose metabolism in skeletal muscle to provide a rational perspective to consider Twist1 as a potential treatment target in clinic. Video Abstract.
Identifiants
pubmed: 37784111
doi: 10.1186/s12964-023-01262-6
pii: 10.1186/s12964-023-01262-6
pmc: PMC10544448
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Lipids
0
Types de publication
Video-Audio Media
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
270Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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