PSGL-1 is an evolutionarily conserved antiviral restriction factor.
HIV-1
PSGL-1
murine leukemia virus
restriction factor
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
medline:
3
10
2023
pubmed:
3
10
2023
entrez:
3
10
2023
Statut:
aheadofprint
Résumé
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to protect the hosts from morbidity, mortality, and even extinction associated with viral infections. There are a number of restriction factors identified so far to counteract HIV infection of the humans. PSGL-1 is a recently characterized human restriction factor that acts both early and late in the viral life cycle, the latter of which is antagonized by the HIV-1 Vpu protein. Here we show
Identifiants
pubmed: 37787515
doi: 10.1128/mbio.00387-23
pmc: PMC10653843
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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