The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides.

Humans Pesticides / toxicity Organophosphorus Compounds / toxicity Parkinson Disease Neurodevelopmental Disorders Neurotoxicity Syndromes / etiology Polymorphism, Single Nucleotide Aryldialkylphosphatase / genetics
ADHD Alzheimer Autism Gene-environment Neurodegenerative Neurodevelopmental Organophosphorus Parkinson Pesticides Polymorphism

Journal

Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615

Informations de publication

Date de publication:
12 2023
Historique:
received: 07 08 2023
accepted: 12 09 2023
medline: 1 11 2023
pubmed: 3 10 2023
entrez: 3 10 2023
Statut: ppublish

Résumé

The toxicology field is concerned with the impact of organophosphorus (OP) compounds on human health. These compounds have been linked to an increased risk of neurological disorders, including neurodegenerative and neurodevelopmental diseases. This article aims to review studies on the role of OP compounds in developing these neurological disorders and explore how genetic variations can affect susceptibility to the neurotoxicity of these pesticides. Studies have shown that exposure to OP compounds can lead to the development of various neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), attention deficit hyperactivity disorder (ADHD), autism, intellectual disability, and other developmental neurotoxicities. Apart from inhibiting the cholinesterase enzyme, OP compounds are believed to cause other pathological mechanisms at both the extracellular level (cholinergic, serotonergic, dopaminergic, glutamatergic, and GABAergic synapses) and the intracellular level (oxidative stress, mitochondrial dysfunction, inflammation, autophagy, and apoptosis) that contribute to these disorders. Specific genetic polymorphisms, including PON1, ABCB1, NOS, DRD4, GST, CYP, and APOE, have increased the risk of developing OP-related neurological disorders.

Identifiants

DOI: 10.1007/s00204-023-03604-2 PMID: 37787774
pubmed: 37787774
doi: 10.1007/s00204-023-03604-2
pii: 10.1007/s00204-023-03604-2
doi:

Substances chimiques

Pesticides 0
Organophosphorus Compounds 0
PON1 protein, human EC 3.1.8.1
Aryldialkylphosphatase EC 3.1.8.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3037-3060

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Sara Mostafalou (S)

Department of Pharmacology & Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

Mohammad Abdollahi (M)

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. mohammad@tums.ac.ir.
ORCID: 0000-0003-0123-1209

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