Conformational Tuning Shapes the Balance between Functional Promiscuity and Specialization in Paralogous

Diazepam Binding Inhibitor / genetics Proteins / metabolism Molecular Conformation Acyl Coenzyme A / metabolism Plasmodium falciparum / genetics

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
17 10 2023
Historique:
medline: 23 10 2023
pubmed: 3 10 2023
entrez: 3 10 2023
Statut: ppublish

Résumé

Paralogous proteins confer enhanced fitness to organisms via complex sequence-conformation codes that shape functional divergence, specialization, or promiscuity. Here, we dissect the underlying mechanism of promiscuous binding versus partial subfunctionalization in paralogues by studying structurally identical acyl-CoA binding proteins (ACBPs) from

Identifiants

DOI: 10.1021/acs.biochem.3c00449 PMID: 37788430
pubmed: 37788430
doi: 10.1021/acs.biochem.3c00449
doi:

Substances chimiques

Diazepam Binding Inhibitor 0
Proteins 0
Acyl Coenzyme A 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2982-2996

Auteurs

Rahul Dani (R)

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.

Westley Pawloski (W)

Center for Biomolecular Structure & Organization, Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.

Dhruv Kumar Chaurasiya (DK)

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
ORCID: 0009-0008-4477-1778

Nonavinakere Seetharam Srilatha (NS)

Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.

Sonal Agarwal (S)

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.

David Fushman (D)

Center for Biomolecular Structure & Organization, Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
ORCID: 0000-0002-6634-8056

Athi N Naganathan (AN)

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
ORCID: 0000-0002-1655-7802

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Inhibiteur de la liaison au diazépam › Conformational Tuning Shapes the Balance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Conformational Tuning Shapes the Balance...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformational Tuning Shapes the Balance...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Conformational Tuning Shapes the Balance...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Conformational Tuning Shapes the Balance...