Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis.
Food intake
Kidney stone disease
Mendelian randomization
Urolithiasis
Journal
Human genomics
ISSN: 1479-7364
Titre abrégé: Hum Genomics
Pays: England
ID NLM: 101202210
Informations de publication
Date de publication:
03 10 2023
03 10 2023
Historique:
received:
15
04
2023
accepted:
04
08
2023
medline:
5
10
2023
pubmed:
4
10
2023
entrez:
3
10
2023
Statut:
epublish
Résumé
Previous studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis. Independent genetic variants associated with different food intakes at a genome-wide significant level were selected from summary-level statistics of genome-wide association studies from the UK Biobank. The association of these instrumental variables with urolithiasis was studied in a cohort from FinnGen Consortium. Among the 15 studied food intake exposures, tea intake (odds ratio [OR] = 0.433, 95% confidence interval [CI] = 0.281-0.667, p value = 1.470 × 10 Genetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter.
Identifiants
pubmed: 37789450
doi: 10.1186/s40246-023-00523-2
pii: 10.1186/s40246-023-00523-2
pmc: PMC10548675
doi:
Banques de données
figshare
['10.6084/m9.figshare.22638838']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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