Small molecule anion carriers facilitate lactate transport in model liposomes and cells.
Biochemistry
Biological sciences
Molecular biology
Natural sciences
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
22
05
2023
revised:
29
08
2023
accepted:
08
09
2023
medline:
4
10
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier, was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that
Identifiants
pubmed: 37790273
doi: 10.1016/j.isci.2023.107898
pii: S2589-0042(23)01975-2
pmc: PMC10543179
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107898Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
A patent application (P202330370) related to this work has been submitted.
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