Radial glia promote microglial development through integrin α

Microglia TGFb signaling development differentiation homeostasis integrin αVβ8 neuroinflammation radial glia stem cells

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
21 Sep 2023
Historique:
pubmed: 4 10 2023
medline: 4 10 2023
entrez: 4 10 2023
Statut: epublish

Résumé

Microglia diversity emerges from interactions between intrinsic genetic programs and environment-derived signals, but how these processes unfold and interact in the developing brain remains unclear. Here, we show that radial glia-expressed integrin beta 8 (ITGB8) expressed in radial glia progenitors activates microglia-expressed TGFβ1, permitting microglial development. Domain-restricted deletion of

Identifiants

DOI: 10.1101/2023.07.13.548459 PMID: 37790363 PMC: PMC10542141
pubmed: 37790363
doi: 10.1101/2023.07.13.548459
pmc: PMC10542141
pii:
doi:

Types de publication

Preprint

Langues

eng

Déclaration de conflit d'intérêts

Declaration of interests D.S. and UCSF hold patents on the uses of antibodies that block the alphavbeta8 integrin. D.S. is a founder and owns stock in Pliant Therapeutics, is on the Scientific Review Board for Genentech and is on the Inflammation Scientific Review Board for Amgen.

Auteurs

Gabriel L McKinsey (GL)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Nicolas Santander (N)

Instituto de Ciencias de la Salud, Universidad de ÓHiggins, Rancagua, Chile.

Xiaoming Zhang (X)

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Kilian Kleemann (K)

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Lauren Tran (L)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Aditya Katewa (A)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Kaylynn Conant (K)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Matthew Barraza (M)

Northwestern University, Department of Neuroscience, Chicago, IL, USA.

Kian Waddell (K)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Carlos Lizama (C)

University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.

Marie La Russa (M)

Stanford University, Department of Bioengineering, Stanford, CA, USA.

Hyun Ji Koo (HJ)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Hyunji Lee (H)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Dibyanti Mukherjee (D)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Helena Paidassi (H)

CIRI Centre International de Recherche en Infectiologie, Univ Lyon Inserm U1111 Université Claude Bernard Lyon 1 CNRS UMR5308 ENS de Lyon F-69007 Lyon France.

E S Anton (ES)

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Kamran Atabai (K)

University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.

Dean Sheppard (D)

University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA.

Oleg Butovsky (O)

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Thomas D Arnold (TD)

University of California San Francisco, Department of Pediatrics and Newborn Brain Research Institute, San Francisco, CA, USA.

Classifications MeSH