Bone mineral density 5 to 11 years after metabolic and bariatric surgery in adolescents with severe obesity compared to peers.

Metabolic and bariatric surgery (MBS) is associated with decreased bone mineral density (BMD) in adults. The long-term impact of MBS during adolescence on BMD is unknown. We report bone health status 5 to 11 years after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) from the Teen-LABS study cohort. Between 2016 and 2022, BMD was measured by dual energy x-ray absorptiometry (DXA) in 106 young adults who had undergone MBS as adolescents. Volumetric BMD by peripheral quantitative computed tomography was measured on a subset. Ninety-one controls who had not undergone MBS were recruited for comparison. Compared to controls, adjusted mean DXA-BMD of the RYGB (n = 58) and VSG (n = 48) groups were lower at the hip (-10.0% and - 6.3%), femoral neck (-9.6% and - 5.7%) and ultra-distal radius (-7.9% and - 7.0%; all BMD, especially of the hip and femoral neck, was lower in young adults who underwent MBS during adolescence compared to matched peers who had not undergone MBS. BMD Z-scores of the femoral neck decreased with time since MBS but were not associated with BMI change.

Déclaration de conflit d'intérêts

Conflicts of interest: HW - Nothing to disclose. TJ – Nothing to disclose. TI – Consultant for Mediflix and receives author royalties from Wolters Kluwer for UpToDate chapter contribution. JR – Receives a donation of drug and placebo for a clinical trial from Boehringer Ingelheim. MM – Intuitive Surgical, Inc (educational honorarium), Intuitive Surgical, Inc (stock ownership – relationship terminated), Lilly USA, LLC (Pediatric Obesity Advisory Board ad hoc member) SS - Consultant for Rhythm Pharmaceuticals CX – Nothing to disclose. HJK - Nothing to disclose.