Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia.
AML
MGA
MYC regulation
RUNX1:RUNX1T1
ncPRC1.6
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
pubmed:
4
10
2023
medline:
4
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in
Identifiants
pubmed: 37790524
doi: 10.21203/rs.3.rs-3315059/v1
pmc: PMC10543392
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL152484
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144653
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflict of interest.