Reintroducing Fenfluramine as a Treatment for Seizures: Current Knowledge, Recommendations and Gaps in Understanding.
Dravet syndrome
drug-resistant epilepsy
fenfluramine
seizures
serotonin
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
07
2023
accepted:
19
09
2023
medline:
4
10
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
Despite the introduction of new anti-seizure medications in recent years, approximately one-third of the epileptic population continues to experience seizures. Recently, the anti-obesity medication fenfluramine (FFA) has been successfully repurposed, and it has received approval from various regulatory agencies for the treatment of seizures associated with Dravet syndrome and Lennox-Gastaut syndrome. The potential antiseizure effects of FFA were initially observed in patients with photosensitive epilepsy in the 1980s but it was not rigorously explored as a treatment option until 30 years later. This narrative review aims to provide an overview of the historical progression of FFA's use, starting from initial clinical observations to preclinical studies and, ultimately, successful clinical trials in the field of epilepsy.
Identifiants
pubmed: 37790801
doi: 10.2147/NDT.S417676
pii: 417676
pmc: PMC10543412
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2013-2025Informations de copyright
© 2023 Dini et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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