Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes.
CYP450
UPLC-MS/MS
drug-drug interaction
inhibition mechanism
vortioxetine
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
04
2023
accepted:
16
08
2023
medline:
4
10
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
Vortioxetine is a novel anti-major depression disorder drug with a high safety profile compared with other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine on cytochrome P450 (CYP450) and the type of inhibitory mechanism were investigated in human and rat liver microsomes. We set up an
Identifiants
pubmed: 37790811
doi: 10.3389/fphar.2023.1199548
pii: 1199548
pmc: PMC10544575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1199548Informations de copyright
Copyright © 2023 Zhan, Wang, Yu, Chen, Xu, Nie and Lin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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