Single-input polarization-sensitive optical coherence tomography through a catheter.

Intravascular polarimetry with catheter-based polarization-sensitive optical coherence tomography (PS-OCT) complements the high-resolution structural tomograms of OCT with morphological contrast available through polarimetry. Its clinical translation has been complicated by the need for modification of conventional OCT hardware to enable polarimetric measurements. Here, we present a signal processing method to reconstruct the polarization properties of tissue from measurements with a single input polarization state, bypassing the need for modulation or multiplexing of input states. Our method relies on a polarization symmetry intrinsic to round-trip measurements and uses the residual spectral variation of the polarization states incident on the tissue to avoid measurement ambiguities. We demonstrate depth-resolved birefringence and optic axis orientation maps reconstructed from

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Déclaration de conflit d'intérêts

Massachusetts General Hospital and Nanyang Technological University have patent licensing arrangements with Terumo Corporation. Drs. Xiong, Liu, Bouma and Villiger have the right to receive royalties as part of the patent licensing arrangements with Terumo Corporation. Dr. Bouma has a financial interest in Soleron Imaging, LLC, a seller of unique optical imaging instruments and components used in this research. Dr. Bouma’s interests were reviewed and are managed by Massachusetts General Hospital and Mass General Brigham in accordance with their conflict of interest policies.