Examining the effects of prenatal alcohol exposure on performance of the sustained attention to response task in children with an FASD.
Fetal Alcohol Spectrum Disorder
Go/No-go
Sustained Attention to Response Task
attention
child behavior
magnetoencephalography
neuropsychology
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
revised:
07
06
2023
received:
02
10
2021
accepted:
10
09
2023
medline:
2
11
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
Prenatal alcohol exposure (PAE), the leading known cause of childhood developmental disability, has long-lasting effects extending throughout the lifespan. It is well documented that children prenatally exposed to alcohol have difficulties inhibiting behavior and sustaining attention. Thus, the Sustained Attention to Response Task (SART), a Go/No-go paradigm, is especially well suited to assess the behavioral and neural functioning characteristics of children with PAE. In this study, we utilized neuropsychological assessment, parent/guardian questionnaires, and magnetoencephalography during SART random and fixed orders to assess characteristics of children 8-12 years old prenatally exposed to alcohol compared to typically developing children. Compared to neurotypical control children, children with a Fetal Alcohol Spectrum Disorder (FASD) diagnosis had significantly decreased performance on neuropsychological measures, had deficiencies in task-based performance, were rated as having increased Attention-Deficit/Hyperactivity Disorder (ADHD) behaviors and as having lower cognitive functioning by their caretakers, and had decreased peak amplitudes in Broadmann's Area 44 (BA44) during SART. Further, MEG peak amplitude in BA44 was found to be significantly associated with neuropsychological test results, parent/guardian questionnaires, and task-based performance such that decreased amplitude was associated with poorer performance. In exploratory analyses, we also found significant correlations between total cortical volume and MEG peak amplitude indicating that the reduced amplitude is likely related in part to reduced overall brain volume often reported in children with PAE. These findings show that children 8-12 years old with an FASD diagnosis have decreased amplitudes in BA44 during SART random order, and that these deficits are associated with multiple behavioral measures.
Identifiants
pubmed: 37792293
doi: 10.1002/hbm.26501
pmc: PMC10619405
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6120-6138Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Hippocampus. 2000;10(1):94-110
pubmed: 10706221
Brain Imaging Behav. 2008 Mar;2(1):39-48
pubmed: 19112522
Semin Clin Neuropsychiatry. 1998 Oct;3(4):262-284
pubmed: 10085215
Neuron. 2000 Apr;26(1):55-67
pubmed: 10798392
Trends Cogn Sci. 2014 Apr;18(4):177-85
pubmed: 24440116
Brain Struct Funct. 2018 Jan;223(1):211-220
pubmed: 28756486
Alcohol Clin Exp Res. 2013 Apr;37(4):644-54
pubmed: 23094678
Alcohol Clin Exp Res. 1996 Sep;20(6):1088-93
pubmed: 8892532
Eur J Neurosci. 2009 Mar;29(6):1302-9
pubmed: 19302166
Neuron. 2003 Jun 5;38(5):831-42
pubmed: 12797966
Am J Obstet Gynecol. 1983 May 1;146(1):41-7
pubmed: 6846423
Neuropsychologia. 1998 Mar;36(3):189-200
pubmed: 9622184
Neurosci Biobehav Rev. 2007;31(2):192-201
pubmed: 16930704
Alcohol. 2022 Mar;99:59-69
pubmed: 34915151
J Dev Behav Pediatr. 2014 Nov-Dec;35(9):598-609
pubmed: 25325756
Pediatrics. 2014 Nov;134(5):855-66
pubmed: 25349310
Neuroimage. 2014 Feb 1;86:381-91
pubmed: 24128740
Cereb Cortex. 2022 Nov 21;32(23):5404-5419
pubmed: 35225334
Alcohol Clin Exp Res. 2010 Jun;34(6):1022-32
pubmed: 20374212
Pediatrics. 2005 Jan;115(1):39-47
pubmed: 15629980
Alcohol Clin Exp Res. 2017 Feb;41(2):334-344
pubmed: 28075019
Pediatrics. 2016 Aug;138(2):
pubmed: 27464676
J Int Neuropsychol Soc. 2008 Nov;14(6):1022-33
pubmed: 18954482
Neuropadiatrie. 1977 Nov;8(4):360-73
pubmed: 201887
Neuroimage. 2010 Apr 15;50(3):1313-9
pubmed: 20056157
Med Biol Eng Comput. 1997 Mar;35(2):135-40
pubmed: 9136207
Biol Psychol. 2000 Jan;51(2-3):87-107
pubmed: 10686361
Psychol Assess. 2009 Sep;21(3):380-9
pubmed: 19719349
Cereb Cortex. 2001 Sep;11(9):825-36
pubmed: 11532888
Alcohol Clin Exp Res. 2012 Oct;36(10):1720-7
pubmed: 22458372
Curr Opin Neurobiol. 2002 Apr;12(2):149-54
pubmed: 12015230
Alcohol Clin Exp Res. 2017 Jan;41(1):96-106
pubmed: 27925227
Alcohol Clin Exp Res. 2017 Dec;41(12):2173-2184
pubmed: 28944474
MMWR Morb Mortal Wkly Rep. 2002 May 24;51(20):433-5
pubmed: 12056499
Brain Sci. 2017 Dec 28;8(1):
pubmed: 29283403
Alcohol Clin Exp Res. 2017 May;41(5):1024-1034
pubmed: 28340498
Alcohol Clin Exp Res. 2007 Aug;31(8):1415-24
pubmed: 17559542
JAMA. 2018 Feb 6;319(5):474-482
pubmed: 29411031
PLoS One. 2011;6(6):e20840
pubmed: 21673969
Alcohol Res Health. 2001;25(3):159-67
pubmed: 11810953
MMWR Recomm Rep. 2005 Oct 28;54(RR-11):1-14
pubmed: 16251866
Dev Disabil Res Rev. 2009;15(3):176-92
pubmed: 19731384
Alcohol Clin Exp Res. 2012 Jan;36(1):83-96
pubmed: 21815896
Am J Med Genet. 1996 Feb 2;61(4):329-39
pubmed: 8834044
Alcohol Clin Exp Res. 2008 Oct;32(10):1732-40
pubmed: 18671811
Hum Brain Mapp. 2023 Dec 1;44(17):6120-6138
pubmed: 37792293
J Dev Behav Pediatr. 2004 Aug;25(4):228-38
pubmed: 15308923
Alcohol. 1987 Jul-Aug;4(4):231-9
pubmed: 3620090
Science. 1998 May 1;280(5364):747-9
pubmed: 9563953
Exp Biol Med (Maywood). 2005 Jun;230(6):357-65
pubmed: 15956765
Exp Brain Res. 2006 Jul;172(3):387-96
pubmed: 16424976
Dev Cogn Neurosci. 2022 Oct;57:101137
pubmed: 35878441
Vision Res. 2002 Dec;42(28):3059-74
pubmed: 12480075
Brain Cogn. 2008 Feb;66(1):57-64
pubmed: 17651880
Teratology. 1997 Nov;56(5):317-26
pubmed: 9451756
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):781-7
pubmed: 9448241
Alcohol Clin Exp Res. 1995 Dec;19(6):1558-64
pubmed: 8749827
Neurosci Biobehav Rev. 2009 May;33(5):647-61
pubmed: 18822313
Neuroimage. 2005 Sep;27(3):587-601
pubmed: 16024257
Alcohol Clin Exp Res. 2016 Jan;40(1):18-32
pubmed: 26727519
Alcohol Clin Exp Res. 1999 Nov;23(11):1808-15
pubmed: 10591598
Pediatrics. 1988 Aug;82(2):147-54
pubmed: 3399287
J Neurosci. 2006 Mar 1;26(9):2424-33
pubmed: 16510720
Psychol Rev. 2004 Oct;111(4):931-959
pubmed: 15482068
Cereb Cortex. 2002 Aug;12(8):856-65
pubmed: 12122034
Eur J Neurosci. 2005 Jun;21(12):3447-52
pubmed: 16026482
Neuroimage. 2018 Apr 1;169:407-418
pubmed: 29278774
Annu Rev Neurosci. 1990;13:25-42
pubmed: 2183676
J Neurosci. 2012 Oct 31;32(44):15243-51
pubmed: 23115162
Child Neuropsychol. 2008 Jan;14(1):71-81
pubmed: 17852119
Behav Brain Res. 2015 Feb 1;278:137-46
pubmed: 25281280
Dev Disabil Res Rev. 2009;15(3):258-67
pubmed: 19731383
Neuron. 2006 Jun 15;50(6):963-74
pubmed: 16772176
Pediatrics. 1984 Sep;74(3):330-5
pubmed: 6472963
Dev Med Child Neurol. 2001 Mar;43(3):148-54
pubmed: 11263683
Alcohol Clin Exp Res. 2019 Jun;43(6):1046-1062
pubmed: 30964197
Alcohol Clin Exp Res. 2002 Feb;26(2):263-71
pubmed: 11964567
Neuropsychologia. 2000;38(9):1292-304
pubmed: 10865105
Curr Opin Psychiatry. 2014 Mar;27(2):98-104
pubmed: 24445400
Behav Brain Res. 2014 Feb 1;259:97-105
pubmed: 24185031
Alcohol. 2006 Oct;40(2):127-33
pubmed: 17307649
Neuroreport. 2001 Mar 5;12(3):515-23
pubmed: 11234756
J Cogn Neurosci. 2010 Jul;22(7):1479-92
pubmed: 19583473
J Neurosci. 2007 Apr 4;27(14):3743-52
pubmed: 17409238
Alcohol Clin Exp Res. 2022 May;46(5):891-906
pubmed: 35347730
Cogn Affect Behav Neurosci. 2007 Dec;7(4):356-66
pubmed: 18189009
Ann N Y Acad Sci. 2011 Apr;1224:40-62
pubmed: 21486295
Brain Sci. 2017 May 31;7(6):
pubmed: 28561761
Can J Psychiatry. 2002 May;47(4):349-54
pubmed: 12025433
Hum Brain Mapp. 2013 Nov;34(11):2852-62
pubmed: 22674650
Res Dev Disabil. 2020 May;100:103617
pubmed: 32203885
Neuropsychologia. 1997 Jun;35(6):747-58
pubmed: 9204482
Neurosci Biobehav Rev. 2007;31(2):278-85
pubmed: 16919732
Eur J Neurosci. 2006 May;23(10):2791-803
pubmed: 16817882
Alcohol Health Res World. 1994;18(1):49-52
pubmed: 31799969
J Cogn Neurosci. 2008 Oct;20(10):1854-65
pubmed: 18370596
Neuroimage. 2004 Jul;22(3):1060-75
pubmed: 15219578