Protocol for evaluating mechanistic pathways associated with HIV acquisition via nested Least Absolute Shrinkage and Selective Operator analysis.
Clinical Protocol
Computer Sciences
Health Sciences
Immunology
Journal
STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
received:
31
03
2023
revised:
13
06
2023
accepted:
19
09
2023
medline:
4
10
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
aheadofprint
Résumé
Statistical analysis to evaluate mechanistic pathways can be limited by non-causal associations as well as co-linearity of high-dimensional data. Here, we present a protocol evaluating statistical associations between multiple exposure variables (sociodemographic and behavioral), immune biomarkers, and HIV acquisition. We describe steps for study setup, combining Least Absolute Shrinkage and Selective Operator with the standard regression approach, and building nested models. This approach can determine to what extent associations between risks for exposure contributes to HIV acquisition with or without associated changes in immune activation. For complete details on the use and execution of this protocol, please refer to Bender Ignacio et al.
Identifiants
pubmed: 37792538
pii: S2666-1667(23)00595-6
doi: 10.1016/j.xpro.2023.102628
pmc: PMC10568409
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102628Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Addiction. 1993 Jun;88(6):791-804
pubmed: 8329970
Clin Infect Dis. 2021 Mar 15;72(6):1042-1050
pubmed: 32107526
Stat Med. 1986 Jan-Feb;5(1):29-36
pubmed: 3961313
Prev Med. 1994 Sep;23(5):587-90
pubmed: 7845919
J Immunol Methods. 2009 Jan 1;340(1):55-64
pubmed: 18983846
Ann Appl Stat. 2011 Mar 1;5(1):468-485
pubmed: 22997542
Stat Med. 1992 Jan 30;11(2):167-78
pubmed: 1579756
iScience. 2022 Nov 19;25(12):105632
pubmed: 36483014
Int J Biostat. 2009 Jan 06;5(1):Article 1
pubmed: 20231866
Stat Sci. 2010 Feb 1;25(1):1-21
pubmed: 20871802
Am J Epidemiol. 2018 Aug 1;187(8):1577-1585
pubmed: 29522079
Front Public Health. 2018 Mar 02;6:57
pubmed: 29552553
AIDS. 2023 Jun 1;37(7):1103-1108
pubmed: 36779502
J Stat Softw. 2014 Jul;58(12):
pubmed: 26257587
Open Forum Infect Dis. 2022 Mar 24;9(6):ofac155
pubmed: 35611350
BMJ. 1994 Oct 29;309(6962):1128
pubmed: 7987107