Sympathetic innervation of the supraclavicular brown adipose tissue: A detailed anatomical study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
01
2023
accepted:
08
08
2023
medline:
6
10
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
The supraclavicular fossa is the dominant location for human brown adipose tissue (BAT). Activation of BAT promotes non-shivering thermogenesis by utilization of glucose and free fatty acids and has been the focus of pharmacological and non-pharmacological approaches for modulation in order to improve body weight and glucose homeostasis. Sympathetic neural control of supraclavicular BAT has received much attention, but its innervation has not been extensively investigated in humans. Dissection of the cervical region in human cadavers was performed to find the distribution of sympathetic nerve branches to supraclavicular fat pad. Furthermore, proximal segments of the 4th cervical nerve were evaluated histologically to assess its sympathetic components. Nerve branches terminating in supraclavicular fat pad were identified in all dissections, including those from the 3rd and 4th cervical nerves and from the cervical sympathetic plexus. Histology of the proximal segments of the 4th cervical nerves confirmed tyrosine hydroxylase positive thin nerve fibers in all fascicles with either a scattered or clustered distribution pattern. The scattered pattern was more predominant than the clustered pattern (80% vs. 20%) across cadavers. These sympathetic nerve fibers occupied only 2.48% of the nerve cross sectional area on average. Human sympathetic nerves use multiple pathways to innervate the supraclavicular fat pad. The present finding serves as a framework for future clinical approaches to activate human BAT in the supraclavicular region.
Sections du résumé
BACKGROUND
The supraclavicular fossa is the dominant location for human brown adipose tissue (BAT). Activation of BAT promotes non-shivering thermogenesis by utilization of glucose and free fatty acids and has been the focus of pharmacological and non-pharmacological approaches for modulation in order to improve body weight and glucose homeostasis. Sympathetic neural control of supraclavicular BAT has received much attention, but its innervation has not been extensively investigated in humans.
METHODS
Dissection of the cervical region in human cadavers was performed to find the distribution of sympathetic nerve branches to supraclavicular fat pad. Furthermore, proximal segments of the 4th cervical nerve were evaluated histologically to assess its sympathetic components.
RESULTS
Nerve branches terminating in supraclavicular fat pad were identified in all dissections, including those from the 3rd and 4th cervical nerves and from the cervical sympathetic plexus. Histology of the proximal segments of the 4th cervical nerves confirmed tyrosine hydroxylase positive thin nerve fibers in all fascicles with either a scattered or clustered distribution pattern. The scattered pattern was more predominant than the clustered pattern (80% vs. 20%) across cadavers. These sympathetic nerve fibers occupied only 2.48% of the nerve cross sectional area on average.
CONCLUSIONS
Human sympathetic nerves use multiple pathways to innervate the supraclavicular fat pad. The present finding serves as a framework for future clinical approaches to activate human BAT in the supraclavicular region.
Identifiants
pubmed: 37792692
doi: 10.1371/journal.pone.0290455
pii: PONE-D-23-01057
pmc: PMC10550181
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0290455Subventions
Organisme : NIH HHS
ID : OT2 OD023848
Pays : United States
Informations de copyright
Copyright: © 2023 Mori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Clin Endocrinol Metab. 2013 Sep;98(9):E1448-55
pubmed: 23824424
Radiology. 2021 May;299(2):396-406
pubmed: 33724063
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8649-8654
pubmed: 28739898
Cell Metab. 2014 Sep 2;20(3):408-15
pubmed: 25185947
PLoS One. 2015 Apr 13;10(4):e0122594
pubmed: 25875082
Neuroscience. 2006 Jun 30;140(2):711-21
pubmed: 16580142
Cell Metab. 2014 Aug 5;20(2):346-58
pubmed: 24981837
Curr Res Physiol. 2021 Jul 11;4:177-182
pubmed: 34746836
Neurochem Int. 1990;17(2):271-9
pubmed: 20504627
Diabetes. 2013 Jun;62(6):1783-90
pubmed: 23704519
Front Neurosci. 2017 Nov 16;11:640
pubmed: 29200996
Rev Endocr Metab Disord. 2022 Feb;23(1):31-41
pubmed: 33712997
J Anat. 1972 May;112(Pt 1):35-9
pubmed: 5086212
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
J Nucl Med. 2017 Jul;58(7):1100-1103
pubmed: 28082439
Lancet. 1947 Sep 27;2(6474):457-60
pubmed: 20265149
Am J Physiol. 1999 Jun;276(6):R1569-78
pubmed: 10362733
Neuroscience. 2002;110(3):515-26
pubmed: 11906790
Nat Med. 2013 May;19(5):635-9
pubmed: 23603815
J Neurosci. 2006 Jan 25;26(4):1190-8
pubmed: 16436606
Ann Surg. 1957 Jan;145(1):94-103
pubmed: 13395288
J Nucl Med. 2021 Jul;62(Suppl 2):34S-43S
pubmed: 34230071
Clin Nucl Med. 2016 Oct;41(10):797-8
pubmed: 27454597
Am J Physiol. 1992 Apr;262(4 Pt 2):R568-73
pubmed: 1314515
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S36-42
pubmed: 20935665
J Nucl Med. 2016 Aug;57(8):1221-5
pubmed: 26795284
Ann N Y Acad Sci. 2019 Oct;1454(1):3-13
pubmed: 31184376
J Nucl Med. 2018 Mar;59(3):516-522
pubmed: 28912148
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):1-6
pubmed: 21088572
Am J Cardiol. 1985 Jul 1;56(1):197-8
pubmed: 4014029
Heart Rhythm. 2014 Aug;11(8):1411-7
pubmed: 24768897
Front Endocrinol (Lausanne). 2020 Sep 25;11:571659
pubmed: 33101206
Diabetes. 2021 Jul;70(7):1473-1485
pubmed: 33858825
PLoS One. 2020 Jul 23;15(7):e0236286
pubmed: 32702004
Neuroscience. 2005;135(2):627-38
pubmed: 16125857
Nat Metab. 2019 Aug;1(8):830-843
pubmed: 32694768