Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis.

Female Humans Osteogenesis Cell Differentiation Osteoporosis / drug therapy Bone Resorption / drug therapy Proto-Oncogene Proteins c-fos / genetics Ovariectomy / adverse effects
RANKL icaritin mitochondria osteoclast osteoporosis

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
03 10 2023
Historique:
received: 23 05 2023
accepted: 21 08 2023
medline: 23 10 2023
pubmed: 4 10 2023
entrez: 4 10 2023
Statut: ppublish

Résumé

A rapidly aging society and longer life expectancy are causing osteoporosis to become a global epidemic. Over the last five decades, a number of drugs aimed at reducing bone resorption or restoring bone mass have been developed, but their efficacy and safety are limited. Icaritin (ICT) is a natural compound extracted from anti-osteoporosis herb

Identifiants

DOI: 10.18632/aging.205068 PMID: 37793008 PMC: PMC10599742
pubmed: 37793008
pii: 205068
doi: 10.18632/aging.205068
pmc: PMC10599742
doi:

Substances chimiques

icaritin UFE666UELY
Proto-Oncogene Proteins c-fos 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10213-10236

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Auteurs

Jun-Ming Huang (JM)

Department of Orthopedics, Shanghai University of Medicine and Health Sciences Affiliated to Zhoupu Hospital, Shanghai, China.
The Orthopedic Hospital, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, China.

Zhe Wang (Z)

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Guo-Bin Qi (GB)

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Qi Lai (Q)

The Orthopedic Hospital, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, China.

A-Lan Jiang (AL)

Medical Innovation Center, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Yue-Qi Zhang (YQ)

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Kun Chen (K)

Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Xiu-Hui Wang (XH)

Department of Orthopedics, Shanghai University of Medicine and Health Sciences Affiliated to Zhoupu Hospital, Shanghai, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines proto-oncogènes c-fos › Icaritin ameliorates RANKL-mediated...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Ovariectomie › Icaritin ameliorates RANKL-mediated...