Tissue Stabilization, Bacterial Adhesion, and Stem Cell Viability in Trans-cinnamaldehyde-conditioned Dentin.
Collagen
Enterococcus faecalis
cross linking
dentin
stem cells
Journal
Journal of endodontics
ISSN: 1878-3554
Titre abrégé: J Endod
Pays: United States
ID NLM: 7511484
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
14
07
2023
revised:
11
09
2023
accepted:
26
09
2023
medline:
24
11
2023
pubmed:
5
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
This laboratory study aimed to evaluate the effect of trans-cinnamaldehyde (TC) conditioning on dentin tissue stabilization, bacterial adhesion, and stem cell toxicity. Dentin beams (n = 204) from extracted human molars were demineralized in phosphoric acid and treated with TC (2.5, 5, and 7.5%), 50% ethanol-water mixture (vehicle control) or 2.5% glutaraldehyde (GA) (positive control) for 30 minutes. Demineralized but untreated specimens served as the negative control. After treatment, collagen crosslinking was characterized by measuring the elastic modulus (E TC-conditioned dentin showed a concentration-dependent increase in E TC conditioning stabilized the dentin and protected it from enzymatic degradation. TC prevented bacterial adhesion on the dentin but maintained stem cell viability.
Identifiants
pubmed: 37793567
pii: S0099-2399(23)00612-X
doi: 10.1016/j.joen.2023.09.011
pii:
doi:
Substances chimiques
cinnamaldehyde
SR60A3XG0F
Collagen
9007-34-5
Glutaral
T3C89M417N
Types de publication
Journal Article
Langues
eng
Pagination
1634-1640Informations de copyright
Copyright © 2023 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.