Practitioner warmth and empathy attenuates the nocebo effect and enhances the placebo effect.

empathy expectations nocebo effect patient-practitioner interaction placebo effect therapeutic alliance

Journal

Applied psychology. Health and well-being
ISSN: 1758-0854
Titre abrégé: Appl Psychol Health Well Being
Pays: England
ID NLM: 101502957

Informations de publication

Date de publication:
04 Oct 2023
Historique:
received: 15 08 2023
accepted: 21 09 2023
medline: 5 10 2023
pubmed: 5 10 2023
entrez: 4 10 2023
Statut: aheadofprint

Résumé

Augmented patient-practitioner interactions that enhance therapeutic alliance can increase the placebo effect to sham treatment. Little is known, however, about the effect of these interactions on maladaptive health outcomes (i.e., the nocebo effect). Healthy participants (N = 84) were randomised to a 3-day course of Oxytocin nasal drops (actually, sham treatment) in conjunction with a high-warmth interaction (Oxy-HW: N = 28), a low-warmth interaction (Oxy-LW: N = 28) or to a no treatment control group (NT: N = 28). All participants were informed that the Oxytocin treatment could increase psychological well-being but was associated with several potential side effects. Treatment-related side effects, unwarned symptoms, and psychological well-being were measured at baseline and all post-treatment days. Side effect reporting was increased in the Oxy-LW condition compared to the other groups across all days. Conversely, increased psychological well-being was observed in the Oxy-HW condition, relative to the other conditions, but only on Day 1. Among those receiving treatment, positive and negative expectations, and treatment-related worry, did not vary by interaction-style, while psychological well-being and side effect reporting were inversely associated at the level of the individual. Results have important implications for practice, suggesting poorer quality interactions may not only reduce beneficial health outcomes but also exacerbate those that are maladaptive.

Identifiants

pubmed: 37793644
doi: 10.1111/aphw.12497
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Australian Research Council Discovery Early Career Research Award
ID : DE180100471

Informations de copyright

© 2023 The Authors. Applied Psychology: Health and Well-Being published by John Wiley & Sons Ltd on behalf of International Association of Applied Psychology.

Références

Aiarzaguena, J. M., Grandes, G., Gaminde, I., Salazar, A., Sanchez, A., & Arino, J. (2007). A randomized controlled clinical trial of a psychosocial and communication intervention carried out by GPs for patients with medically unexplained symptoms. Psychological Medicine, 37(2), 283-294. https://doi.org/10.1017/S0033291706009536
Barnes, K., Babbage, E., Barker, J., Jain, N., & Faasse, K. (2023). The role of positive information provision in open-label placebo effects. Applied Psychology. Health and Well-Being, n/a(n/a). https://doi.org/10.1111/aphw.12444
Barnes, K., Faasse, K., & Colagiuri, B. (2023). The impact of side effect framing on COVID-19 booster vaccine intentions in an Australian sample. Vaccine, 41(12), 2046-2054. https://doi.org/10.1016/j.vaccine.2023.02.023
Barnes, K., Faasse, K., Geers, A. L., Helfer, S. G., Sharpe, L., Colloca, L., & Colagiuri, B. (2019). Can positive framing reduce nocebo side effects? Current evidence and recommendation for future research [mini review]. Frontiers in Pharmacology, 10, 167. https://doi.org/10.3389/fphar.2019.00167
Barnes, K., McNair, N. A., Harris, J. A., Sharpe, L., & Colagiuri, B. (2021). In anticipation of pain: Expectancy modulates corticospinal excitability, autonomic response, and pain perception. Pain, 162(8), 2287-2296. https://doi.org/10.1097/j.pain.0000000000002222
Bartley, H., Faasse, K., Horne, R., & Petrie, K. J. (2016). You Can't always get what you want: The influence of choice on nocebo and placebo responding. Annals of Behavioral Medicine, 50(3), 445-451. https://doi.org/10.1007/s12160-016-9772-1
Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015). Fitting linear mixed-effects models using lme4. Journal of Statistical Software, 67(1), 1-48. https://doi.org/10.18637/jss.v067.i01
Cals, J. W. L., Butler, C. C., Hopstaken, R. M., Hood, K., & Dinant, G.-J. (2009). Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: Cluster randomised trial. BMJ, 338, b1374. https://doi.org/10.1136/bmj.b1374
Chassany, O., Boureau, F., Liard, F., Bertin, P., Serrie, A., Ferran, P., Keddad, K., Jolivet-Landreau, I., & Marchand, S. (2006). Effects of training on general practitioners' management of pain in osteoarthritis: A randomized multicenter study. The Journal of Rheumatology, 33(9), 1827-1834.
Chen, P.-H. A., Cheong, J. H., Jolly, E., Elhence, H., Wager, T. D., & Chang, L. J. (2019). Socially transmitted placebo effects. Nature Human Behaviour, 3(12), 1295-1305. https://doi.org/10.1038/s41562-019-0749-5
Cleland, J. A., Hall, S., Price, D., & Lee, A. J. (2007). An exploratory, pragmatic, cluster randomised trial of practice nurse training in the use of asthma action plans. Primary Care Respiratory Journal, 16(5), 311-318. https://doi.org/10.3132/pcrj.2007.00063
Colagiuri, B., & Quinn, V. F. (2018). Autonomic arousal as a mechanism of the persistence of nocebo hyperalgesia. The Journal of Pain, 19(5), 476-486. https://doi.org/10.1016/j.jpain.2017.12.006
Colagiuri, B., Quinn, V. F., & Colloca, L. (2015). Nocebo hyperalgesia, partial reinforcement, and extinction. The Journal of Pain, 16(10), 995-1004. https://doi.org/10.1016/j.jpain.2015.06.012
Colloca, L., Petrovic, P., Wager, T. D., Ingvar, M., & Benedetti, F. (2010). How the number of learning trials affects placebo and nocebo responses. Pain, 151(2), 430-439. https://doi.org/10.1016/j.pain.2010.08.007
Czerniak, E., Biegon, A., Ziv, A., Karnieli-Miller, O., Weiser, M., Alon, U., & Citron, A. (2016). Manipulating the placebo response in experimental pain by altering Doctor's performance style [original research]. Frontiers in Psychology, 7, 874. https://doi.org/10.3389/fpsyg.2016.00874
Darnall, B. D., & Colloca, L. (2018). Chapter Six - Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit. In L. Colloca (Ed.), International review of neurobiology (Vol. 139) (pp. 129-157). Academic Press. https://doi.org/10.1016/bs.irn.2018.07.022
Darragh, M., Yow, B., Kieser, A., Booth, R. J., Kydd, R. R., & Consedine, N. S. (2016). A take-home placebo treatment can reduce stress, anxiety and symptoms of depression in a non-patient population. The Australian and New Zealand Journal of Psychiatry, 50(9), 858-865. https://doi.org/10.1177/0004867415621390
Derksen, F., Bensing, J., & Lagro-Janssen, A. (2013). Effectiveness of empathy in general practice: A systematic review. British Journal of General Practice, 63(606), e76. https://doi.org/10.3399/bjgp13X660814
Di Blasi, Z., Harkness, E., Ernst, E., Georgiou, A., & Kleijnen, J. (2001). Influence of context effects on health outcomes: A systematic review. The Lancet, 357(9258), 757-762. https://doi.org/10.1016/S0140-6736(00)04169-6
El Brihi, J., Horne, R., & Faasse, K. (2019). Prescribing placebos: An experimental examination of the role of dose, expectancies, and adherence in open-label placebo effects. Annals of Behavioral Medicine, 53(1), 16-28. https://doi.org/10.1093/abm/kay011
Ellingsen, D.-M., Isenburg, K., Jung, C., Lee, J., Gerber, J., Mawla, I., Sclocco, R., Grahl, A., Anzolin, A., Edwards, R. R., Kelley, J. M., Kirsch, I., Kaptchuk, T. J., & Napadow, V. (2023). Brain-to-brain mechanisms underlying pain empathy and social modulation of pain in the patient-clinician interaction. Proceedings of the National Academy of Sciences, 120(26), e2212910120. https://doi.org/10.1073/pnas.2212910120
Ellingsen, D.-M., Isenburg, K., Jung, C., Lee, J., Gerber, J., Mawla, I., Sclocco, R., Jensen, K. B., Edwards, R. R., Kelley, J. M., Kirsch, I., Kaptchuk, T. J., & Napadow, V. (2020). Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction. Science Advances, 6(43), eabc1304. https://doi.org/10.1126/sciadv.abc1304
Elliott, R., Bohart, A. C., Watson, J. C., & Murphy, D. (2018). Therapist empathy and client outcome: An updated meta-analysis. Psychotherapy, 55(4), 399-410. https://doi.org/10.1037/pst0000175
Enck, P., Bingel, U., Schedlowski, M., & Rief, W. (2013). The placebo response in medicine: Minimize, maximize or personalize? Nature Reviews Drug Discovery, 12(3), 191-204. https://doi.org/10.1038/nrd3923
Faasse, K., Cundy, T., Gamble, G., & Petrie, K. J. (2013). The effect of an apparent change to a branded or generic medication on drug effectiveness and side effects. Psychosomatic Medicine, 75(1), 90-96. https://doi.org/10.1097/PSY.0b013e3182738826
Faasse, K., Cundy, T., & Petrie, K. J. (2009). Thyroxine: Anatomy of a health scare. BMJ, 339, b5613. https://doi.org/10.1136/bmj.b5613
Faasse, K., Grey, A., Jordan, R., Garland, S., & Petrie, K. J. (2015). Seeing is believing: Impact of social modeling on placebo and nocebo responding. Health Psychology, 34(8), 880-885. https://doi.org/10.1037/hea0000199
Faasse, K., Helfer, S. G., Barnes, K., Colagiuri, B., & Geers, A. L. (2019). Experimental assessment of nocebo effects and nocebo side effects: Definitions, study design, and implications for psychiatry and beyond [opinion]. Frontiers in Psychiatry, 10. https://doi.org/10.3389/fpsyt.2019.00396
Faasse, K., Huynh, A., Pearson, S., Geers, A. L., Helfer, S. G., & Colagiuri, B. (2019). The influence of side effect information framing on nocebo effects. Annals of Behavioral Medicine, 53(7), 621-629. https://doi.org/10.1093/abm/kay071
Faasse, K., Martin, L. R., Grey, A., Gamble, G., & Petrie, K. J. (2016). Impact of brand or generic labeling on medication effectiveness and side effects. Health Psychology, 35(2), 187-190. https://doi.org/10.1037/hea0000282
Faasse, K., Perera, A., Loveys, K., Grey, A., & Petrie, K. J. (2017). Enhancing treatment effectiveness through social modelling: A pilot study. Psychology & Health, 32(5), 626-637. https://doi.org/10.1080/08870446.2017.1293056
Faasse, K., Yeom, B., Parkes, B., Kearney, J., & Petrie, K. J. (2018). The influence of social modeling, gender, and empathy on treatment side effects. Annals of Behavioral Medicine, 52(7), 560-570. https://doi.org/10.1093/abm/kax025
Ferreira, P. H., Ferreira, M. L., Maher, C. G., Refshauge, K. M., Latimer, J., & Adams, R. D. (2013). The therapeutic Alliance between clinicians and patients predicts outcome in chronic low Back pain. Physical Therapy, 93(4), 470-478. https://doi.org/10.2522/ptj.20120137
Fuentes, J., Armijo-Olivo, S., Funabashi, M., Miciak, M., Dick, B., Warren, S., Rashiq, S., Magee, D. J., & Gross, D. P. (2014). Enhanced therapeutic Alliance modulates pain intensity and muscle pain sensitivity in patients with chronic low Back pain: An experimental controlled study. Physical Therapy, 94(4), 477-489. https://doi.org/10.2522/ptj.20130118
Fujimori, M., Shirai, Y., Asai, M., Kubota, K., Katsumata, N., & Uchitomi, Y. (2014). Effect of communication skills training program for oncologists based on patient preferences for communication when receiving bad news: A randomized controlled trial. Journal of Clinical Oncology, 32(20), 2166-2172. https://doi.org/10.1200/JCO.2013.51.2756
Gaab, J., Kossowsky, J., Ehlert, U., & Locher, C. (2019). Effects and components of placebos with a psychological treatment rationale - Three randomized-controlled studies. Scientific Reports, 9(1), 1421. https://doi.org/10.1038/s41598-018-37945-1
Geers, A. L., Faasse, K., Guevarra, D. A., Clemens, K. S., Helfer, S. G., & Colagiuri, B. (2021). Affect and emotions in placebo and nocebo effects: What do we know so far? Social and Personality Psychology Compass, 15(1), e12575. https://doi.org/10.1111/spc3.12575
Henry, J. D., & Crawford, J. R. (2005). The short-form version of the depression anxiety stress scales (DASS-21): Construct validity and normative data in a large non-clinical sample. The British Journal of Clinical Psychology, 44(Pt 2), 227-239. https://doi.org/10.1348/014466505X29657
Hojat, M., Louis, D. Z., Markham, F. W., Wender, R., Rabinowitz, C., & Gonnella, J. S. (2011). Physicians' empathy and clinical outcomes for diabetic patients. Academic Medicine, 86(3), 359-364. https://doi.org/10.1097/ACM.0b013e3182086fe1
Howe, L. C., Goyer, J. P., & Crum, A. J. (2017). Harnessing the placebo effect: Exploring the influence of physician characteristics on placebo response. Health Psychology, 36(11), 1074-1082. https://doi.org/10.1037/hea0000499
Howe, L. C., Leibowitz, K. A., & Crum, A. J. (2019). When your doctor “gets it” and “gets you”: The critical role of competence and warmth in the patient-provider interaction [hypothesis and theory]. Frontiers in Psychiatry, 10. https://doi.org/10.3389/fpsyt.2019.00475
Jannis, A., Bernd, L., Maja Alicia, G., Keith, P., Johannes, L., Yvonne, N., & Meike, S.-M. (2020). Development of the generic, multidimensional treatment expectation questionnaire (TEX-Q) through systematic literature review, expert surveys and qualitative interviews. BMJ Open, 10(8), e036169. https://doi.org/10.1136/bmjopen-2019-036169
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., Park, M., Rivers, A. L., McManus, C., Kokkotou, E., Drossman, D. A., Goldman, P., & Lembo, A. J. (2008). Components of placebo effect: Randomised controlled trial in patients with irritable bowel syndrome. BMJ, 336(7651), 999-1003. https://doi.org/10.1136/bmj.39524.439618.25
Kelley, J. M., Kraft-Todd, G., Schapira, L., Kossowsky, J., & Riess, H. (2014). The influence of the patient-clinician relationship on healthcare outcomes: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE, 9(4), e94207. https://doi.org/10.1371/journal.pone.0094207
Keysers, C., & Gazzola, V. (2023). Vicarious emotions of fear and pain in rodents. Affective Science. https://doi.org/10.1007/s42761-023-00198-x
Kube, T., Glombiewski, J. A., & Rief, W. (2018). Using different expectation mechanisms to optimize treatment of patients with medical conditions: A systematic review. Psychosomatic Medicine, 80(6), 535-543. https://doi.org/10.1097/PSY.0000000000000596
Lenth, R. V. (2023). Emmeans: Estimated marginal means, aka least-squares means. In
Lovibond, S. H., & Lovibond, P. F. (1995). Manual for the depression anxiety stress scales (2nd ed.). Psychology Foundation of Australia.
MacKrill, K., Gamble, G. D., Bean, D. J., Cundy, T., & Petrie, K. J. (2019). Evidence of a media-induced nocebo response following a Nationwide antidepressant drug switch. Clinical Psychology in Europe, 1(1), 1-12. https://doi.org/10.32872/cpe.v1i1.29642
Mao, A., Barnes, K., Sharpe, L., Geers, A. L., Helfer, S. G., Faasse, K., & Colagiuri, B. (2021). Using positive attribute framing to attenuate nocebo side effects: A Cybersickness study. Annals of Behavioral Medicine, 55(8), 769-778. https://doi.org/10.1093/abm/kaaa115
Mattick, R. P., & Clarke, J. C. (1998). Development and validation of measures of social phobia scrutiny fear and social interaction anxiety11Editor's note: This article was written before the development of some contemporary measures of social phobia, such as the social phobia and anxiety inventory (turner et al., 1989). We have invited this article for publication because of the growing interest in the scales described therein. S.T. Behaviour Research and Therapy, 36(4), 455-470.
Mercer, S. W., Maxwell, M., Heaney, D., & Watt, G. C. M. (2004). The consultation and relational empathy (CARE) measure: Development and preliminary validation and reliability of an empathy-based consultation process measure. Family Practice, 21(6), 699-705. https://doi.org/10.1093/fampra/cmh621
Morin, C. M., Belleville, G., Bélanger, L., & Ivers, H. (2011). The insomnia severity index: Psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep, 34(5), 601-608. https://doi.org/10.1093/sleep/34.5.601
Pan, Y., Kinitz, T., Stapic, M., & Nestoriuc, Y. (2019). Minimizing drug adverse events by informing about the nocebo effect-An experimental study [Original Research. Frontiers in Psychiatry, 10. https://doi.org/10.3389/fpsyt.2019.00504
Pärnamets, P., Espinosa, L., & Olsson, A. (2020). Physiological synchrony predicts observational threat learning in humans. Proceedings of the Royal Society B: Biological Sciences, 287(1927), 20192779. https://doi.org/10.1098/rspb.2019.2779
Petrie, K. J., Faasse, K., Crichton, F., & Grey, A. (2014). How common are symptoms? Evidence from a New Zealand national telephone survey. BMJ Open, 4(6), e005374. https://doi.org/10.1136/bmjopen-2014-005374
Price, D. D., Finniss, D. G., & Benedetti, F. (2008). A comprehensive review of the placebo effect: Recent advances and current thought. Annual Review of Psychology, 59(1), 565-590. https://doi.org/10.1146/annurev.psych.59.113006.095941
Quinn, V., Pearson, S., Huynh, A., Nicholls, K., Barnes, K., & Faasse, K. (2023). The influence of video-based social modelling on the nocebo effect. Journal of Psychosomatic Research, 165, 111136. https://doi.org/10.1016/j.jpsychores.2022.111136
R Core Team. (2023). R: A Language and Environment for Statistical Computing. In R Foundation for statistical computing.
Rakel, D., Barrett, B., Zhang, Z., Hoeft, T., Chewning, B., Marchand, L., & Scheder, J. (2011). Perception of empathy in the therapeutic encounter: Effects on the common cold. Patient Education and Counseling, 85(3), 390-397. https://doi.org/10.1016/j.pec.2011.01.009
Reader, T., Gillespie, A., & Roberts, J. (2014). Patient complaints in healthcare systems: A systematic review and coding taxonomy. BMJ Quality &Amp;Amp; Safety, 23(8), 678.
Reicherts, P., Gerdes, A. B. M., Pauli, P., & Wieser, M. J. (2016). Psychological placebo and nocebo effects on pain rely on expectation and previous experience. The Journal of Pain, 17(2), 203-214. https://doi.org/10.1016/j.jpain.2015.10.010
Rief, W., Barsky, A. J., Glombiewski, J. A., Nestoriuc, Y., Glaesmer, H., & Braehler, E. (2011). Assessing general side effects in clinical trials: Reference data from the general population. Pharmacoepidemiology and Drug Safety, 20(4), 405-415. https://doi.org/10.1002/pds.2067
Rooney, T., Sharpe, L., Todd, J., Richmond, B., & Colagiuri, B. (2022). The relationship between expectancy, anxiety, and the nocebo effect: A systematic review and meta-analysis with recommendations for future research. Health Psychology Review, 1-28. https://doi.org/10.1080/17437199.2022.2125894
Russell, K., Duncan, M., Price, M., Mosewich, A., Ellmers, T., & Hill, M. (2022). A comparison of placebo and nocebo effects on objective and subjective postural stability: A double-edged sword? [Original Research. Frontiers in Human Neuroscience, 16, 967722. https://doi.org/10.3389/fnhum.2022.967722
Shalaby, R., Adu, M. K., El Gindi, H. M., & Agyapong, V. I. O. (2022). Text messages in the field of mental health: Rapid review of the reviews [Review. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.921982
Singmann, H., Bolker, B., Westfall, J., Aust, F., & Ben-Shachar, M. S. (2023). Afex: Analysis of factorial experiments. In
Stewart-Williams, S., & Podd, J. (2004). The placebo effect: Dissolving the expectancy versus conditioning debate. Psychological Bulletin, 130(2), 324-340. https://doi.org/10.1037/0033-2909.130.2.324
Street, R. L., & Voigt, B. (1997). Patient participation in deciding breast cancer treatment and subsequent quality of life. Medical Decision Making, 17(3), 298-306. https://doi.org/10.1177/0272989X9701700306
Tang, B., Barnes, K., Geers, A., Livesey, E., & Colagiuri, B. (2022). Choice and the placebo effect: A meta-analysis. Annals of Behavioral Medicine, 56(10), 977-988. https://doi.org/10.1093/abm/kaab111
Turnwald, B. P., Goyer, J. P., Boles, D. Z., Silder, A., Delp, S. L., & Crum, A. J. (2019). Learning one's genetic risk changes physiology independent of actual genetic risk. Nature Human Behaviour, 3(1), 48-56. https://doi.org/10.1038/s41562-018-0483-4
Verheul, W., Sanders, A., & Bensing, J. (2010). The effects of physicians' affect-oriented communication style and raising expectations on analogue patients' anxiety, affect and expectancies. Patient Education and Counseling, 80(3), 300-306. https://doi.org/10.1016/j.pec.2010.06.017
Vögtle, E., Barke, A., & Kröner-Herwig, B. (2013). Nocebo hyperalgesia induced by social observational learning. Pain, 154(8), 1427-1433. https://doi.org/10.1016/j.pain.2013.04.041
Wampold, B. E. (2021). Healing in a social context: The importance of clinician and patient relationship [Review. Frontiers in Pain Research, 2, 684768. https://doi.org/10.3389/fpain.2021.684768
Ward, M. M., Sundaramurthy, S., Lotstein, D., Bush, T. M., Neuwelt, C. M., & Street, R. L. Jr. (2003). Participatory patient-physician communication and morbidity in patients with systemic lupus erythematosus. Arthritis Care & Research, 49(6), 810-818. https://doi.org/10.1002/art.11467
Yamagishi, T., & Yamagishi, M. (1994). Trust and commitment in the United States and Japan. Motivation and Emotion, 18(2), 129-166. https://doi.org/10.1007/BF02249397
Zolnierek, K. B., & Dimatteo, M. R. (2009). Physician communication and patient adherence to treatment: A meta-analysis. Medical Care, 47(8), 826-834. https://doi.org/10.1097/MLR.0b013e31819a5acc

Auteurs

Kirsten Barnes (K)

School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.

Rachelle Wang (R)

School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.

Kate Faasse (K)

School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.

Classifications MeSH